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Proceedings Paper

Digital detection of biomarkers for high-sensitivity diagnostics at low-cost
Author(s): M. Selim Ünlü; John Connor; Steve Scherr; George G. Daaboul; Elif Ç. Seymour; Nese Lortlar Ünlü; Jacob Trueb; Derin D. Sevenler; Oguzhan Avci
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Paper Abstract

We have demonstrated Interferometric Reflectance Imaging Sensor (IRIS) with the ability to detect single nanoscale particles. By extending single-particle IRIS to in-liquid dynamic imaging, we demonstrated real-time digital detection of individual viral pathogens as well as single molecules labeled with Au nanoparticles. With this technique we demonstrate real-time simultaneous detection of multiple targets in a single sample, as well as quantitative dynamic detection of individual biomolecular interactions for reaction kinetics measurements. This approach promises to simplify and reduce the cost of rapid diagnostics.

Paper Details

Date Published: 11 March 2016
PDF: 6 pages
Proc. SPIE 9699, Optics and Biophotonics in Low-Resource Settings II, 969902 (11 March 2016); doi: 10.1117/12.2218530
Show Author Affiliations
M. Selim Ünlü, Boston Univ. Photonics Ctr. (United States)
John Connor, Boston Univ. Photonics Ctr. (United States)
Steve Scherr, Boston Univ. Photonics Ctr. (United States)
George G. Daaboul, Nanoview Inc. (United States)
Elif Ç. Seymour, Boston Univ. Photonics Ctr. (United States)
Aselsan (Turkey)
Nese Lortlar Ünlü, Boston Univ. Photonics Ctr. (United States)
Bahçesehir Univ. (Turkey)
Jacob Trueb, Boston Univ. Photonics Ctr. (United States)
Derin D. Sevenler, Boston Univ. Photonics Ctr. (United States)
Oguzhan Avci, Boston Univ. Photonics Ctr. (United States)


Published in SPIE Proceedings Vol. 9699:
Optics and Biophotonics in Low-Resource Settings II
David Levitz; Aydogan Ozcan; David Erickson, Editor(s)

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