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Proceedings Paper

What advances in microscopy are required for combined MRI and optical functional brain imaging? (Conference Presentation)
Author(s): David Kleinfeld

Paper Abstract

This overview talk will focus on forward-looking scientific needs and physical limits to images of neuronal processes. The challenge in nervous systems is that the basic unit for "switching" events in the nervous system occurs on the one micrometer scale of synaptic spines, while computations involve communication between individual neurons across the full expanse of cortex, which is ten millimeters for mouse cortex. I will address hoped-for advances in optical microscopy, within the context of existing and proposed contrast mechanisms of neuronal function, that span the four orders of magnitude of length scales for neuronal processing

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9717, Adaptive Optics and Wavefront Control for Biological Systems II, 97170D (27 April 2016); doi: 10.1117/12.2218121
Show Author Affiliations
David Kleinfeld, Univ. of California, San Diego (United States)


Published in SPIE Proceedings Vol. 9717:
Adaptive Optics and Wavefront Control for Biological Systems II
Thomas G. Bifano; Joel Kubby; Sylvain Gigan, Editor(s)

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