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Proceedings Paper

Mechanistic exploration of a bi-directional PDT-based combination in pancreatic cancer (Conference Presentation)
Author(s): Huang-Chiao Huang; Srivalleesha Mallidi; Joyce Liu; Chun-Te Chiang; Zhiming Mai; Ruth Goldschmidt; Imran Rizvi; Neema Ebrahim-Zadeh; Tayyaba Hasan
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Paper Abstract

It is increasingly evident that the most effective cancer treatments will involve interactive regimens that target multiple non-overlapping pathways, preferably such that each component enhances the others to improve outcomes while minimizing systemic toxicities. Toward this goal, we developed a combination of photodynamic therapy and irinotecan, which mechanistically cooperate with each other, beyond their individual tumor destruction pathways, to cause synergistic reduction in orthotopic pancreatic tumor burden. A three-way mechanistic basis of the observed the synergism will be discussed: (i) PDT downregulates drug efflux transporters to increase intracellular irinotecan levels. (ii) Irinotecan reduces the expression of hypoxia-induced marker, which is upregulated by PDT. (iii) PDT downregulates irinotecan-induced survivin expression to amplify the apoptotic and anti-proliferative effects. The clinical translation potential of the combination will also be highlighted.

Paper Details

Date Published: 26 April 2016
PDF: 1 pages
Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 96940W (26 April 2016); doi: 10.1117/12.2217925
Show Author Affiliations
Huang-Chiao Huang, Massachusetts General Hospital (United States)
Srivalleesha Mallidi, Massachusetts General Hospital (United States)
Joyce Liu, Massachusetts General Hospital (United States)
Chun-Te Chiang, Massachusetts General Hospital (United States)
Zhiming Mai, Massachusetts General Hospital (United States)
Ruth Goldschmidt, Massachusetts General Hospital (United States)
Imran Rizvi, Massachusetts General Hospital (United States)
Neema Ebrahim-Zadeh, Massachusetts General Hospital (United States)
Tayyaba Hasan, Massachusetts General Hospital (United States)

Published in SPIE Proceedings Vol. 9694:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV
David H. Kessel; Tayyaba Hasan, Editor(s)

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