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Proceedings Paper

Modular microfluidic cartridge-based universal diagnostic system for global health applications
Author(s): Holger Becker; Richard Klemm; William Dietze; Wallace White; Nadine Hlawatsch; Susanne Freyberg; Christian Moche; Peter Dailey; Claudia Gärtner
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Paper Abstract

Current microfluidics-enabled point-of-care diagnostic systems are typically designed specifically for one assay type, e.g. a molecular diagnostic assay for a single disease of a class of diseases. This approach often leads to high development cost and a significant training requirement for users of different instruments. We have developed an open platform diagnostic system which allows to run molecular, immunological and clinical assays on a single instrument platform with a standardized microfluidic cartridge architecture in an automated sample-in answer-out fashion. As examples, a molecular diagnostic assay for tuberculosis, an immunoassay for HIV p24 and a clinical chemistry assay for ALT liver function have been developed and results of their pre-clinical validation are presented.

Paper Details

Date Published: 18 March 2016
PDF: 4 pages
Proc. SPIE 9705, Microfluidics, BioMEMS, and Medical Microsystems XIV, 970514 (18 March 2016); doi: 10.1117/12.2217892
Show Author Affiliations
Holger Becker, microfluidic ChipShop GmbH (Germany)
Richard Klemm, microfluidic ChipShop GmbH (Germany)
William Dietze, Stratos Product Development LLC (United States)
Wallace White, Stratos Product Development LLC (United States)
Nadine Hlawatsch, microfluidic ChipShop GmbH (Germany)
Susanne Freyberg, microfluidic ChipShop GmbH (Germany)
Christian Moche, microfluidic ChipShop GmbH (Germany)
Peter Dailey, Halteres Associates (United States)
Claudia Gärtner, microfluidic ChipShop GmbH (Germany)

Published in SPIE Proceedings Vol. 9705:
Microfluidics, BioMEMS, and Medical Microsystems XIV
Bonnie L. Gray; Holger Becker, Editor(s)

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