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Proceedings Paper

First multiphoton tomography of brain in man
Author(s): Karsten König; Sven R. Kantelhardt; Darius Kalasauskas; Ella Kim; Alf Giese
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Paper Abstract

We report on the first two-photon in vivo brain tissue imaging study in man. High resolution in vivo histology by multiphoton tomography (MPT) including two-photon FLIM was performed in the operation theatre during neurosurgery to evaluate the feasibility to detect label-free tumor borders with subcellular resolution. This feasibility study demonstrates, that MPT has the potential to identify tumor borders on a cellular level in nearly real-time.

Paper Details

Date Published: 9 March 2016
PDF: 6 pages
Proc. SPIE 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation, 96900A (9 March 2016); doi: 10.1117/12.2217730
Show Author Affiliations
Karsten König, JenLab GmbH (Germany)
Univ. des Saarlandes (Germany)
Sven R. Kantelhardt, Johannes Gutenberg Univ. (Germany)
Darius Kalasauskas, Johannes Gutenberg Univ. (Germany)
Ella Kim, Johannes Gutenberg Univ. (Germany)
Alf Giese, Johannes Gutenberg Univ. (Germany)


Published in SPIE Proceedings Vol. 9690:
Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation
Steen J. Madsen; Victor X. D. Yang; E. Duco Jansen; Qingming Luo; Samarendra K. Mohanty; Nitish V. Thakor, Editor(s)

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