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Proceedings Paper

Miniature objective lens for array digital pathology: design improvement based on clinical evaluation
Author(s): Brian McCall; Mark Pierce; Edward A. Graviss; Rebecca R. Richards-Kortum; Tomasz S. Tkaczyk
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Paper Abstract

A miniature objective designed for digital detection of Mycobacterium tuberculosis (MTB) was evaluated for diagnostic accuracy. The objective was designed for array microscopy, but fabricated and evaluated at this stage of development as a single objective. The counts and diagnoses of patient samples were directly compared for digital detection and standard microscopy. The results were found to be correlated and highly concordant. The evaluation of this lens by direct comparison to standard fluorescence sputum smear microscopy presented unique challenges and led to some new insights in the role played by the system parameters of the microscope. The design parameters and how they were developed are reviewed in light of these results. New system parameters are proposed with the goal of easing the challenges of evaluating the miniature objective and maintaining the optical performance that produced the agreeable results presented without over-optimizing. A new design is presented that meets and exceeds these criteria.

Paper Details

Date Published: 23 March 2016
PDF: 6 pages
Proc. SPIE 9791, Medical Imaging 2016: Digital Pathology, 97910K (23 March 2016); doi: 10.1117/12.2217430
Show Author Affiliations
Brian McCall, Fresnel Technologies Inc. (United States)
Mark Pierce, Rutgers Univ. (United States)
Edward A. Graviss, The Methodist Hospital Research Institute (United States)
Rebecca R. Richards-Kortum, Rice Univ. (United States)
Tomasz S. Tkaczyk, Rice Univ. (United States)


Published in SPIE Proceedings Vol. 9791:
Medical Imaging 2016: Digital Pathology
Metin N. Gurcan; Anant Madabhushi, Editor(s)

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