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Proceedings Paper

Robust dynamic myocardial perfusion CT deconvolution using adaptive-weighted tensor total variation regularization
Author(s): Changfei Gong; Dong Zeng; Zhaoying Bian; Jing Huang; Xinyu Zhang; Hua Zhang; Lijun Lu; Qianjin Feng; Zhengrong Liang; Jianhua Ma
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Paper Abstract

Dynamic myocardial perfusion computed tomography (MPCT) is a promising technique for diagnosis and risk stratification of coronary artery disease by assessing the myocardial perfusion hemodynamic maps (MPHM). Meanwhile, the repeated scanning of the same region results in a relatively large radiation dose to patients potentially. In this work, we present a robust MPCT deconvolution algorithm with adaptive-weighted tensor total variation regularization to estimate residue function accurately under the low-dose context, which is termed `MPD-AwTTV'. More specifically, the AwTTV regularization takes into account the anisotropic edge property of the MPCT images compared with the conventional total variation (TV) regularization, which can mitigate the drawbacks of TV regularization. Subsequently, an effective iterative algorithm was adopted to minimize the associative objective function. Experimental results on a modified XCAT phantom demonstrated that the present MPD-AwTTV algorithm outperforms and is superior to other existing deconvolution algorithms in terms of noise-induced artifacts suppression, edge details preservation and accurate MPHM estimation.

Paper Details

Date Published: 30 March 2016
PDF: 9 pages
Proc. SPIE 9783, Medical Imaging 2016: Physics of Medical Imaging, 97833D (30 March 2016); doi: 10.1117/12.2217351
Show Author Affiliations
Changfei Gong, Southern Medical Univ. (China)
Dong Zeng, Southern Medical Univ. (China)
Zhaoying Bian, Southern Medical Univ. (China)
Jing Huang, Southern Medical Univ. (China)
Xinyu Zhang, Southern Medical Univ. (China)
Hua Zhang, Southern Medical Univ. (China)
Lijun Lu, Southern Medical Univ. (China)
Qianjin Feng, Southern Medical Univ. (China)
Zhengrong Liang, State Univ. of New York (United States)
Jianhua Ma, Southern Medical Univ. (China)


Published in SPIE Proceedings Vol. 9783:
Medical Imaging 2016: Physics of Medical Imaging
Despina Kontos; Thomas G. Flohr, Editor(s)

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