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Proceedings Paper

A 3D high resolution ex vivo white matter atlas of the common squirrel monkey (saimiri sciureus) based on diffusion tensor imaging
Author(s): Yurui Gao; Prasanna Parvathaneni; Kurt G. Schilling; Feng Wang; Iwona Stepniewska; Zhoubing Xu; Ann S. Choe; Zhaohua Ding; John C. Gore; Li min Chen; Bennett A. Landman; Adam W. Anderson
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Paper Abstract

Modern magnetic resonance imaging (MRI) brain atlases are high quality 3-D volumes with specific structures labeled in the volume. Atlases are essential in providing a common space for interpretation of results across studies, for anatomical education, and providing quantitative image-based navigation. Extensive work has been devoted to atlas construction for humans, macaque, and several non-primate species (e.g., rat). One notable gap in the literature is the common squirrel monkey – for which the primary published atlases date from the 1960’s. The common squirrel monkey has been used extensively as surrogate for humans in biomedical studies, given its anatomical neuro-system similarities and practical considerations. This work describes the continued development of a multi-modal MRI atlas for the common squirrel monkey, for which a structural imaging space and gray matter parcels have been previously constructed. This study adds white matter tracts to the atlas. The new atlas includes 49 white matter (WM) tracts, defined using diffusion tensor imaging (DTI) in three animals and combines these data to define the anatomical locations of these tracks in a standardized coordinate system compatible with previous development. An anatomist reviewed the resulting tracts and the inter-animal reproducibility (i.e., the Dice index of each WM parcel across animals in common space) was assessed. The Dice indices range from 0.05 to 0.80 due to differences of local registration quality and the variation of WM tract position across individuals. However, the combined WM labels from the 3 animals represent the general locations of WM parcels, adding basic connectivity information to the atlas.

Paper Details

Date Published: 21 March 2016
PDF: 8 pages
Proc. SPIE 9784, Medical Imaging 2016: Image Processing, 97843K (21 March 2016); doi: 10.1117/12.2217325
Show Author Affiliations
Yurui Gao, Vanderbilt Univ. (United States)
Prasanna Parvathaneni, Vanderbilt Univ. (United States)
Kurt G. Schilling, Vanderbilt Univ. (United States)
Feng Wang, Vanderbilt Univ. (United States)
Iwona Stepniewska, Vanderbilt Univ. (United States)
Zhoubing Xu, Vanderbilt Univ. (United States)
Ann S. Choe, Vanderbilt Univ. (United States)
Zhaohua Ding, Vanderbilt Univ. (United States)
John C. Gore, Vanderbilt Univ. (United States)
Li min Chen, Vanderbilt Univ. (United States)
Bennett A. Landman, Vanderbilt Univ. (United States)
Adam W. Anderson, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 9784:
Medical Imaging 2016: Image Processing
Martin A. Styner; Elsa D. Angelini, Editor(s)

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