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Proceedings Paper

Semi-automated registration of pre- and intra-operative liver CT for image-guided interventions
Author(s): Gokhan Gunay; Luu Manh Ha; Theo van Walsum; Stefan Klein
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Paper Abstract

Percutaneous radio frequency ablation is a method for liver tumor treatment when conventional surgery is not an option. It is a minimally invasive treatment and may be performed under CT image guidance if the tumor does not give sufficient contrast on ultrasound images. For optimal guidance, registration of the pre-operative contrast-enhanced CT image to the intra-operative CT image is hypothesized to improve guidance. This is a highly challenging registration task due to large differences in pose and image quality. In this study, we introduce a semi-automated registration algorithm to address this problem. The method is based on a conventional nonrigid intensity-based registration framework, extended with a novel point-to-surface constraint. The point-to-surface constraint serves to improve the alignment of the liver boundary, while requiring minimal user interaction during the operation. The method assumes that a liver segmentation of the pre-operative CT is available. After an initial nonrigid registration without the point-to-surface constraint, the operator clicks a few points on the liver surface at those regions where the nonrigid registration seems inaccurate. In a subsequent registration step, these points on the intra-operative image are driven towards the liver surface on the preoperative image, using a penalty term added to the registration cost function. The method is evaluated on five clinical datasets and it is shown to improve registration compared with conventional rigid and nonrigid registrations in all cases.

Paper Details

Date Published: 21 March 2016
PDF: 8 pages
Proc. SPIE 9784, Medical Imaging 2016: Image Processing, 97841N (21 March 2016); doi: 10.1117/12.2217206
Show Author Affiliations
Gokhan Gunay, Erasmus MC (Netherlands)
Luu Manh Ha, Erasmus MC (Netherlands)
Theo van Walsum, Erasmus MC (Netherlands)
Stefan Klein, Erasmus MC (Netherlands)


Published in SPIE Proceedings Vol. 9784:
Medical Imaging 2016: Image Processing
Martin A. Styner; Elsa D. Angelini, Editor(s)

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