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Proceedings Paper

Fusion of multi-parametric MRI and temporal ultrasound for characterization of prostate cancer: in vivo feasibility study
Author(s): Farhad Imani; Sahar Ghavidel; Purang Abolmaesumi; Siavash Khallaghi; Eli Gibson; Amir Khojaste; Mena Gaed; Madeleine Moussa; Jose A. Gomez; Cesare Romagnoli; Derek W. Cool; Matthew Bastian-Jordan; Zahra Kassam; D. Robert Siemens; Michael Leveridge; Silvia Chang; Aaron Fenster; Aaron D. Ward; Parvin Mousavi
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Paper Abstract

Recently, multi-parametric Magnetic Resonance Imaging (mp-MRI) has been used to improve the sensitivity of detecting high-risk prostate cancer (PCa). Prior to biopsy, primary and secondary cancer lesions are identified on mp-MRI. The lesions are then targeted using TRUS guidance. In this paper, for the first time, we present a fused mp-MRI-temporal-ultrasound framework for characterization of PCa, in vivo. Cancer classification results obtained using temporal ultrasound are fused with those achieved using consolidated mp-MRI maps determined by multiple observers. We verify the outcome of our study using histopathology following deformable registration of ultrasound and histology images. Fusion of temporal ultrasound and mp-MRI for characterization of the PCa results in an area under the receiver operating characteristic curve (AUC) of 0.86 for cancerous regions with Gleason scores (GSs)≥3+3, and AUC of 0.89 for those with GSs≥3+4.

Paper Details

Date Published: 24 March 2016
PDF: 7 pages
Proc. SPIE 9785, Medical Imaging 2016: Computer-Aided Diagnosis, 97851K (24 March 2016); doi: 10.1117/12.2217205
Show Author Affiliations
Farhad Imani, The Univ. of British Columbia (Canada)
Sahar Ghavidel, Queen's Univ. (Canada)
Purang Abolmaesumi, The Univ. of British Columbia (Canada)
Siavash Khallaghi, The Univ. of British Columbia (Canada)
Eli Gibson, Univ. College London (United Kingdom)
Amir Khojaste, Queen's Univ. (Canada)
Mena Gaed, Western Univ. (Canada)
Madeleine Moussa, London Health Sciences Ctr. (Canada)
Jose A. Gomez, London Health Sciences Ctr. (Canada)
Cesare Romagnoli, Western Univ. (Canada)
Derek W. Cool, Western Univ. (Canada)
Matthew Bastian-Jordan, Western Univ. (Canada)
Zahra Kassam, Western Univ. (Canada)
D. Robert Siemens, Kingston General Hospital (Canada)
Michael Leveridge, Kingston General Hospital (Canada)
Silvia Chang, Vancouver General Hospital (Canada)
Aaron Fenster, Western Univ. (Canada)
Aaron D. Ward, Western Univ. (Canada)
Parvin Mousavi, Queen's Univ. (Canada)


Published in SPIE Proceedings Vol. 9785:
Medical Imaging 2016: Computer-Aided Diagnosis
Georgia D. Tourassi; Samuel G. Armato, Editor(s)

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