Share Email Print
cover

Proceedings Paper

Correlation between diffusion kurtosis and NODDI metrics in neonates and young children
Author(s): Shaheen Ahmed; Zhiyue J. Wang; Jonathan M. Chia; Nancy K. Rollins
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Diffusion Tensor Imaging (DTI) uses single shell gradient encoding scheme for studying brain tissue diffusion. NODDI (Neurite Orientation Dispersion and Density Imaging) incorporates a gradient scheme with multiple b-values which is used to characterize neurite density and coherence of neuron fiber orientations. Similarly, the diffusion kurtosis imaging also uses a multiple shell scheme to quantify non-Gaussian diffusion but does not assume a tissue model like NODDI. In this study we investigate the connection between metrics derived by NODDI and DKI in children with ages from 46 weeks to 6 years. We correlate the NODDI metrics and Kurtosis measures from the same ROIs in multiple brain regions. We compare the range of these metrics between neonates (46 - 47 weeks), infants (2 -10 months) and young children (2 – 6 years). We find that there exists strong correlation between neurite density vs. mean kurtosis, orientation dispersion vs. kurtosis fractional anisotropy (FA) in pediatric brain imaging.

Paper Details

Date Published: 29 March 2016
PDF: 7 pages
Proc. SPIE 9788, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, 97881F (29 March 2016); doi: 10.1117/12.2217197
Show Author Affiliations
Shaheen Ahmed, Children's Medical Ctr. (United States)
Univ. of Texas Southwestern Medical Ctr. (United States)
Zhiyue J. Wang, Children's Medical Ctr. (United States)
Univ. of Texas Southwestern Medical Ctr. (United States)
Jonathan M. Chia, Philips Healthcare (United States)
Nancy K. Rollins, Children's Medical Ctr. (United States)
Univ. of Texas Southwestern Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 9788:
Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging
Barjor Gimi; Andrzej Krol, Editor(s)

© SPIE. Terms of Use
Back to Top