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Proceedings Paper

Comprehensive serial study of dynamic remodeling of atherosclerotic coronary arteries using IVUS
Author(s): Zhi Chen; Andreas Wahle; Ling Zhang; Tomas Kovarnik; John J. Lopez; Milan Sonka
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Paper Abstract

We present a semi-automated approach to comprehensively examine coronary remodeling over the entire length of intravascular ultrasound (IVUS) imaged vessels. Serial measurements at baseline and 12-month follow-up are analyzed rather than static data obtained at a single time point. Every IVUS pullback is segmented automatically, and then reviewed and algorithmically refined by an expert using a computer-aided just-enough-interaction approach. Subsequently, pairs of serial IVUS pullbacks are registered automatically using 3D graph optimization approach. Based on plaque volume increases or decreases over time, pullback frames are divided into two groups — progression and regression. It is shown that plaque progression rates are positively correlated with percent stenosis (PS) indices (p≪0.01) while plaque regression rates are negatively correlated with percent stenosis indices (p≪0.01). Moreover, for the progression group, adventitia area increases in direct relation with the baseline percent stenosis (p=0.007) when PS is less than 50%. Significance of such a correlation is not observed when percent stenosis exceeds 50%. Conversely, for the regression group, change of adventitia area is relatively constant for percent stenosis <50%; but decreases in direct relation with baseline stenosis (p≪0.01) when stenosis > 50%. This strongly suggests that lipid lowering treatment may effectively suppress plaque progression and accelerate plaque regression, especially for larger values of percent stenosis, and further accelerate the corresponding adventitia-remodeling process.

Paper Details

Date Published: 29 March 2016
PDF: 6 pages
Proc. SPIE 9788, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, 97880Y (29 March 2016); doi: 10.1117/12.2217152
Show Author Affiliations
Zhi Chen, Iowa Institute for Biomedical Imaging, The Univ. of Iowa (United States)
Andreas Wahle, Iowa Institute for Biomedical Imaging, The Univ. of Iowa (United States)
Ling Zhang, Iowa Institute for Biomedical Imaging, The Univ. of Iowa (United States)
Tomas Kovarnik, First Faculty of Medicine, Charles Univ. in Prague (Czech Republic)
General Univ. Hospital in Prague (Czech Republic)
John J. Lopez, Loyola Univ. Stritch School of Medicine (United States)
Milan Sonka, Iowa Institute for Biomedical Imaging, The Univ. of Iowa (United States)


Published in SPIE Proceedings Vol. 9788:
Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging
Barjor Gimi; Andrzej Krol, Editor(s)

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