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Proceedings Paper

Regional placental blood oxygen level dependent (BOLD) changes with gestational age in normally developing pregnancies using long duration R2* mapping in utero
Author(s): Manjiri Dighe; Yun Jung Kim; Sharmishtaa Seshamani; Ania I. Blazejewska; Susan Mckown; Jason Caucutt; Christopher Gatenby; Colin Studholme
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Paper Abstract

The aim of this study was to examine the use of R2* mapping in maternal and fetal sub-regions of the placenta with the aim of providing a reference for blood oxygenation levels during normative development. There have been a number of MR relaxation studies of placental tissues in-utero, but none have reported R2* value changes with age, or examined differences in sub-regions of the placenta. Here specialized long-duration Multi-frame R2* imaging was used to create a stable estimate for R2* values in different placental regions in healthy pregnant volunteers not imaged for clinical reasons. 27 subjects were recruited and scanned up to 3 times during their pregnancy. A multi-slice dual echo EPI based BOLD acquisition was employed and repeated between 90 and 150 times over 3 to 5 minutes to provide a high accuracy estimate of the R2* signal level. Acquisitions were also repeated in 13 cases within a visit to evaluate reproducibility of the method in a given subject. Experimental results showed R2* measurements were highly repeatable within a visit with standard deviation of (0.76). Plots of all visits against gestational age indicated clear correlations showing decreases in R2* with age. This increase was consistent was also consistent over time in multiple visits of the same volunteer during their pregnancy. Maternal and fetal regional changes with gestational age followed the same trend with increase in R2* over the gestational age.

Paper Details

Date Published: 29 March 2016
PDF: 7 pages
Proc. SPIE 9788, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, 97881H (29 March 2016); doi: 10.1117/12.2217137
Show Author Affiliations
Manjiri Dighe, Univ. of Washington Medical Ctr. (United States)
Yun Jung Kim, Univ. of Washington Medical Ctr. (United States)
Sharmishtaa Seshamani, Univ. of Washington Medical Ctr. (United States)
Ania I. Blazejewska, Univ. of Washington Medical Ctr. (United States)
Susan Mckown, Univ. of Washington Medical Ctr. (United States)
Jason Caucutt, ITHS, Univ. of Washington (United States)
Christopher Gatenby, Univ. of Washington Medical Ctr. (United States)
Colin Studholme, Univ. of Washington Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 9788:
Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging
Barjor Gimi; Andrzej Krol, Editor(s)

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