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Proceedings Paper

Coded aperture x-ray diffraction imaging with transmission computed tomography side-information
Author(s): Ikenna Odinaka; Joel A. Greenberg; Yan Kaganovsky; Andrew Holmgren; Mehadi Hassan; David G. Politte; Joseph A. O'Sullivan; Lawrence Carin; David J. Brady
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Paper Abstract

Coded aperture X-ray diffraction (coherent scatter spectral) imaging provides fast and dose-efficient measurements of the molecular structure of an object. The information provided is spatially-dependent and material-specific, and can be utilized in medical applications requiring material discrimination, such as tumor imaging. However, current coded aperture coherent scatter spectral imaging system assume a uniformly or weakly attenuating object, and are plagued by image degradation due to non-uniform self-attenuation. We propose accounting for such non-uniformities in the self-attenuation by utilizing an X-ray computed tomography (CT) image (reconstructed attenuation map). In particular, we present an iterative algorithm for coherent scatter spectral image reconstruction, which incorporates the attenuation map, at different stages, resulting in more accurate coherent scatter spectral images in comparison to their uncorrected counterpart. The algorithm is based on a spectrally grouped edge-preserving regularizer, where the neighborhood edge weights are determined by spatial distances and attenuation values.

Paper Details

Date Published: 25 March 2016
PDF: 9 pages
Proc. SPIE 9783, Medical Imaging 2016: Physics of Medical Imaging, 978323 (25 March 2016); doi: 10.1117/12.2216915
Show Author Affiliations
Ikenna Odinaka, Duke Univ. (United States)
Joel A. Greenberg, Duke Univ. (United States)
Yan Kaganovsky, Duke Univ. (United States)
Andrew Holmgren, Duke Univ. (United States)
Mehadi Hassan, Duke Univ. (United States)
David G. Politte, Washington Univ. in St. Louis (United States)
Joseph A. O'Sullivan, Washington Univ. in St. Louis (United States)
Lawrence Carin, Duke Univ. (United States)
David J. Brady, Duke Univ. (United States)


Published in SPIE Proceedings Vol. 9783:
Medical Imaging 2016: Physics of Medical Imaging
Despina Kontos; Thomas G. Flohr, Editor(s)

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