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Proceedings Paper

800-MeV magnetic-focused flash proton radiography for high-contrast imaging of low-density biologically-relevant targets using an inverse-scatter collimator
Author(s): Matthew S. Freeman; Jason Allison; Camilo Espinoza; John Jerome Goett; Gary Hogan; Brian Hollander; Kris Kwiatkowski; Julian Lopez; Fesseha Mariam; Michael Martinez; Jason Medina; Patrick Medina; Frank E. Merrill; Deborah Morley; Chris Morris; Matthew Murray; Paul Nedrow; Alexander Saunders; Tamsen Schurman; Thomas Sisneros; Amy Tainter; Frans Trouw; Dale Tupa; Josh Tybo; Carl Wilde
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Paper Abstract

Proton radiography shows great promise as a tool to guide proton beam therapy (PBT) in real time. Here, we demonstrate two ways in which the technology may progress towards that goal. Firstly, with a proton beam that is 800 MeV in energy, target tissue receives a dose of radiation with very tight lateral constraint. This could present a benefit over the traditional treatment energies of ~200 MeV, where up to 1 cm of lateral tissue receives scattered radiation at the target. At 800 MeV, the beam travels completely through the object with minimal deflection, thus constraining lateral dose to a smaller area. The second novelty of this system is the utilization of magnetic quadrupole refocusing lenses that mitigate the blur caused by multiple Coulomb scattering within an object, enabling high resolution imaging of thick objects, such as the human body. This system is demonstrated on ex vivo salamander and zebrafish specimens, as well as on a realistic hand phantom. The resulting images provide contrast sufficient to visualize thin tissue, as well as fine detail within the target volumes, and the ability to measure small changes in density. Such a system, combined with PBT, would enable the delivery of a highly specific dose of radiation that is monitored and guided in real time.

Paper Details

Date Published: 25 March 2016
PDF: 11 pages
Proc. SPIE 9783, Medical Imaging 2016: Physics of Medical Imaging, 97831X (25 March 2016); doi: 10.1117/12.2216862
Show Author Affiliations
Matthew S. Freeman, Los Alamos National Lab. (United States)
Jason Allison, Los Alamos National Lab. (United States)
Camilo Espinoza, Los Alamos National Lab. (United States)
John Jerome Goett, Los Alamos National Lab. (United States)
Gary Hogan, Los Alamos National Lab. (United States)
Brian Hollander, Los Alamos National Lab. (United States)
Kris Kwiatkowski, Los Alamos National Lab. (United States)
Julian Lopez, Los Alamos National Lab. (United States)
Fesseha Mariam, Los Alamos National Lab. (United States)
Michael Martinez, Los Alamos National Lab. (United States)
Jason Medina, Los Alamos National Lab. (United States)
Patrick Medina, Los Alamos National Lab. (United States)
Frank E. Merrill, Los Alamos National Lab. (United States)
Deborah Morley, Los Alamos National Lab. (United States)
Chris Morris, Los Alamos National Lab. (United States)
Matthew Murray, Los Alamos National Lab. (United States)
Paul Nedrow, Los Alamos National Lab. (United States)
Alexander Saunders, Los Alamos National Lab. (United States)
Tamsen Schurman, Los Alamos National Lab. (United States)
Thomas Sisneros, Los Alamos National Lab. (United States)
Amy Tainter, Los Alamos National Lab. (United States)
Frans Trouw, Los Alamos National Lab. (United States)
Dale Tupa, Los Alamos National Lab. (United States)
Josh Tybo, Los Alamos National Lab. (United States)
Carl Wilde, Los Alamos National Lab. (United States)


Published in SPIE Proceedings Vol. 9783:
Medical Imaging 2016: Physics of Medical Imaging
Despina Kontos; Thomas G. Flohr, Editor(s)

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