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Proceedings Paper

High-spatial-resolution nanoparticle x-ray fluorescence tomography
Author(s): Jakob C. Larsson; William Vågberg; Carmen Vogt; Ulf Lundström; Daniel H. Larsson; Hans M. Hertz
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Paper Abstract

X-ray fluorescence tomography (XFCT) has potential for high-resolution 3D molecular x-ray bio-imaging. In this technique the fluorescence signal from targeted nanoparticles (NPs) is measured, providing information about the spatial distribution and concentration of the NPs inside the object. However, present laboratory XFCT systems typically have limited spatial resolution (>1 mm) and suffer from long scan times and high radiation dose even at high NP concentrations, mainly due to low efficiency and poor signal-to-noise ratio. We have developed a laboratory XFCT system with high spatial resolution (sub-100 μm), low NP concentration and vastly decreased scan times and dose, opening up the possibilities for in-vivo small-animal imaging research. The system consists of a high-brightness liquid-metal-jet microfocus x-ray source, x-ray focusing optics and an energy-resolving photon-counting detector. By using the source’s characteristic 24 keV line-emission together with carefully matched molybdenum nanoparticles the Compton background is greatly reduced, increasing the SNR. Each measurement provides information about the spatial distribution and concentration of the Mo nanoparticles. A filtered back-projection method is used to produce the final XFCT image.

Paper Details

Date Published: 25 March 2016
PDF: 6 pages
Proc. SPIE 9783, Medical Imaging 2016: Physics of Medical Imaging, 97831V (25 March 2016); doi: 10.1117/12.2216770
Show Author Affiliations
Jakob C. Larsson, KTH Royal Institute of Technology (Sweden)
William Vågberg, KTH Royal Institute of Technology (Sweden)
Carmen Vogt, KTH Royal Institute of Technology (Sweden)
Ulf Lundström, KTH Royal Institute of Technology (Sweden)
Daniel H. Larsson, KTH Royal Institute of Technology (Sweden)
Hans M. Hertz, KTH Royal Institute of Technology (Sweden)


Published in SPIE Proceedings Vol. 9783:
Medical Imaging 2016: Physics of Medical Imaging
Despina Kontos; Thomas G. Flohr, Editor(s)

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