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Proceedings Paper

3D ultrasound computer tomography: update from a clinical study
Author(s): T. Hopp; M. Zapf; E. Kretzek; J. Henrich; A. Tukalo; H. Gemmeke; C. Kaiser; J. Knaudt; N. V. Ruiter
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Paper Abstract

Ultrasound Computer Tomography (USCT) is a promising new imaging method for breast cancer diagnosis. We developed a 3D USCT system and tested it in a pilot study with encouraging results: 3D USCT was able to depict two carcinomas, which were present in contrast enhanced MRI volumes serving as ground truth. To overcome severe differences in the breast shape, an image registration was applied. We analyzed the correlation between average sound speed in the breast and the breast density estimated from segmented MRIs and found a positive correlation with R=0.70. Based on the results of the pilot study we now carry out a successive clinical study with 200 patients. For this we integrated our reconstruction methods and image post-processing into a comprehensive workflow. It includes a dedicated DICOM viewer for interactive assessment of fused USCT images. A new preview mode now allows intuitive and faster patient positioning. We updated the USCT system to decrease the data acquisition time by approximately factor two and to increase the penetration depth of the breast into the USCT aperture by 1 cm. Furthermore the compute-intensive reflectivity reconstruction was considerably accelerated, now allowing a sub-millimeter volume reconstruction in approximately 16 minutes. The updates made it possible to successfully image first patients in our ongoing clinical study.

Paper Details

Date Published: 1 April 2016
PDF: 9 pages
Proc. SPIE 9790, Medical Imaging 2016: Ultrasonic Imaging and Tomography, 97900A (1 April 2016); doi: 10.1117/12.2216686
Show Author Affiliations
T. Hopp, Karlsruhe Institute of Technology (Germany)
M. Zapf, Karlsruhe Institute of Technology (Germany)
E. Kretzek, Karlsruhe Institute of Technology (Germany)
J. Henrich, Karlsruhe Institute of Technology (Germany)
A. Tukalo, Karlsruhe Institute of Technology (Germany)
H. Gemmeke, Karlsruhe Institute of Technology (Germany)
C. Kaiser, Univ. Medical Ctr. Mannheim, Institute for Clinical Radiology and Nuclear Medicine (Germany)
J. Knaudt, Univ. Medical Ctr. Mannheim, Institute for Clinical Radiology and Nuclear Medicine (Germany)
N. V. Ruiter, Karlsruhe Institute of Technology (Germany)

Published in SPIE Proceedings Vol. 9790:
Medical Imaging 2016: Ultrasonic Imaging and Tomography
Neb Duric; Brecht Heyde, Editor(s)

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