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Proceedings Paper

Voxel based morphometry in optical coherence tomography: validation and core findings
Author(s): Bhavna J. Antony; Min Chen; Aaron Carass; Bruno M. Jedynak; Omar Al-Louzi; Sharon D. Solomon; Shiv Saidha; Peter A. Calabresi; Jerry L. Prince
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Paper Abstract

Optical coherence tomography (OCT) of the human retina is now becoming established as an important modality for the detection and tracking of various ocular diseases. Voxel based morphometry (VBM) is a long standing neuroimaging analysis technique that allows for the exploration of the regional differences in the brain. There has been limited work done in developing registration based methods for OCT, which has hampered the advancement of VBM analyses in OCT based population studies. Following on from our recent development of an OCT registration method, we explore the potential benefits of VBM analysis in cohorts of healthy controls (HCs) and multiple sclerosis (MS) patients. Specifically, we validate the stability of VBM analysis in two pools of HCs showing no significant difference between the two populations. Additionally, we also present a retrospective study of age and sex matched HCs and relapsing remitting MS patients, demonstrating results consistent with the reported literature while providing insight into the retinal changes associated with this MS subtype.

Paper Details

Date Published: 29 March 2016
PDF: 8 pages
Proc. SPIE 9788, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, 97880P (29 March 2016); doi: 10.1117/12.2216096
Show Author Affiliations
Bhavna J. Antony, Johns Hopkins Univ. (United States)
Min Chen, The Univ. of Pennsylvania (United States)
Aaron Carass, Johns Hopkins Univ. (United States)
Bruno M. Jedynak, Portland State Univ. (United States)
Omar Al-Louzi, Johns Hopkins Univ. School of Medicine (United States)
Sharon D. Solomon, Johns Hopkins Univ. School of Medicine (United States)
Shiv Saidha, Johns Hopkins Univ. School of Medicine (United States)
Peter A. Calabresi, Johns Hopkins Univ. School of Medicine (United States)
Jerry L. Prince, Johns Hopkins Univ. (United States)


Published in SPIE Proceedings Vol. 9788:
Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging
Barjor Gimi; Andrzej Krol, Editor(s)

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