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Proceedings Paper

The morphological changes in lymphoid organs and peripheral blood indicators in rats after peroral administration of gold nanoparticles
Author(s): A. B. Bucharskaya; S. S. Pakhomy; O. V. Zlobina; G. N. Maslyakova; O. V. Matveeva; I. O. Bugaeva; N. A. Navolokin; B. N. Khlebtsov; V. A. Bogatyrev; N. G. Khlebtsov; V. V. Tuchin
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Paper Abstract

The wide application of nanotechnologies in medicine requires the careful study of various aspects of their potential safety. The effects of prolonged peroral administration of gold nanoparticles on morphological changes in lymphoid organs and indicators of peripheral blood of laboratory animals were investigated in experiment. The gold nanospheres functionalized with thiolated polyethylene glycol sizes 2, 15 and 50 nm were administered orally for 15 days to outbred white rats at a dosage of 190 μg/kg of animal body weight. The standard histological and hematological staining were used for morphological study of lymphoid organs and bone marrow smears. The size-dependent decrease of the number of neutrophils and lymphocytes was noted in the study of peripheral blood, especially pronounced after administration of gold nanoparticles with size of 50 nm. The stimulation of myelocytic germ of hematopoiesis was recorded at morphological study of the bone marrow. The signs of strengthening of the processes of differentiation and maturation of cellular elements were found in lymph nodes, which were showed as the increasing number of immunoblasts and large lymphocytes. The quantitative changes of cellular component morphology of lymphoid organs due to activation of migration, proliferation and differentiation of immune cells indicate the presence of immunostimulation effect of gold nanoparticles.

Paper Details

Date Published: 9 March 2016
PDF: 9 pages
Proc. SPIE 9709, Biophotonics and Immune Responses XI, 97090V (9 March 2016); doi: 10.1117/12.2216045
Show Author Affiliations
A. B. Bucharskaya, Saratov State Medical Univ. (Russian Federation)
S. S. Pakhomy, Saratov State Medical Univ. (Russian Federation)
O. V. Zlobina, Saratov State Medical Univ. (Russian Federation)
G. N. Maslyakova, Saratov State Medical Univ. (Russian Federation)
O. V. Matveeva, Saratov State Medical Univ. (Russian Federation)
I. O. Bugaeva, Saratov State Medical Univ. (Russian Federation)
N. A. Navolokin, Saratov State Medical Univ. (Russian Federation)
B. N. Khlebtsov, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russian Federation)
V. A. Bogatyrev, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russian Federation)
N. G. Khlebtsov, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russian Federation)
Saratov National Research State Univ. (Russian Federation)
V. V. Tuchin, Saratov National Research State Univ. (Russian Federation)
Institute of Precise Mechanics and Control (Russian Federation)
Tomsk National Research State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 9709:
Biophotonics and Immune Responses XI
Wei R. Chen, Editor(s)

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