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Proceedings Paper

Simultaneous segmentation of retinal surfaces and microcystic macular edema in SDOCT volumes
Author(s): Bhavna J. Antony; Andrew Lang; Emily K. Swingle; Omar Al-Louzi; Aaron Carass; Sharon Solomon; Peter A. Calabresi; Shiv Saidha; Jerry L. Prince
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Paper Abstract

Optical coherence tomography (OCT) is a noninvasive imaging modality that has begun to find widespread use in retinal imaging for the detection of a variety of ocular diseases. In addition to structural changes in the form of altered retinal layer thicknesses, pathological conditions may also cause the formation of edema within the retina. In multiple sclerosis, for instance, the nerve fiber and ganglion cell layers are known to thin. Additionally, the formation of pseudocysts called microcystic macular edema (MME) have also been observed in the eyes of about 5% of MS patients, and its presence has been shown to be correlated with disease severity. Previously, we proposed separate algorithms for the segmentation of retinal layers and MME, but since MME mainly occurs within specific regions of the retina, a simultaneous approach is advantageous. In this work, we propose an automated globally optimal graph-theoretic approach that simultaneously segments the retinal layers and the MME in volumetric OCT scans. SD-OCT scans from one eye of 12 MS patients with known MME and 8 healthy controls were acquired and the pseudocysts manually traced. The overall precision and recall of the pseudocyst detection was found to be 86.0% and 79.5%, respectively.

Paper Details

Date Published: 21 March 2016
PDF: 9 pages
Proc. SPIE 9784, Medical Imaging 2016: Image Processing, 97841C (21 March 2016); doi: 10.1117/12.2214676
Show Author Affiliations
Bhavna J. Antony, Johns Hopkins Univ. (United States)
Andrew Lang, Johns Hopkins Univ. (United States)
Emily K. Swingle, The Ohio State Univ. (United States)
Omar Al-Louzi, Johns Hopkins Univ. School of Medicine (United States)
Aaron Carass, Johns Hopkins Univ. (United States)
Sharon Solomon, Johns Hopkins Univ. School of Medicine (United States)
Peter A. Calabresi, Johns Hopkins Univ. School of Medicine (United States)
Shiv Saidha, Johns Hopkins Univ. School of Medicine (United States)
Jerry L. Prince, Johns Hopkins Univ. (United States)

Published in SPIE Proceedings Vol. 9784:
Medical Imaging 2016: Image Processing
Martin A. Styner; Elsa D. Angelini, Editor(s)

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