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Proceedings Paper

Comparison of the photothermal effects of 808nm gold nanorod and indocyanine green solutions using an 805nm diode laser
Author(s): Aamr M. Hasanjee; Feifan Zhou; Connor West; Kegan Silk; Austin Doughty; Cody F. Bahavar; Wei R. Chen
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Paper Abstract

Non-invasive laser immunotherapy (NLIT) is a treatment method for metastatic cancer which combines noninvasive laser irradiation with immunologically modified nanostructures to ablate a primary tumor and induce a systemic anti-tumor response. To further expand the development of NLIT, two different photosensitizing agents were compared: gold nanorods (GNR) with an optical absorption peak of 808 nm and indocyanine green (ICG) with an optical absorption peak of ~800 nm. Various concentrations of GNR and ICG solutions were irradiated at different power densities using an 805 nm diode laser, and the temperature of the solutions was monitored during irradiation using a thermal camera. For comparison, dye balls made up of a 1:1 volume ratio of gel solution to GNR or ICG solution were placed in phantom gels and were then irradiated using the 805 nm diode laser to imitate the effect of laser irradiation on in vivo tumors. Non-invasive laser irradiation of GNR solution for 2 minutes resulted in a maximum increase in temperature by 31.8 °C. Additionally, similar irradiation of GNR solution dye ball within phantom gel for 10 minutes resulted in a maximum temperature increase of 8.2 °C. Comparatively, non-invasive laser irradiation of ICG solution for 2 minutes resulted in a maximum increase in temperature by 28.0 °C. Similar irradiation of ICG solution dye ball within phantom gel for 10 minutes yielded a maximum temperature increase of only 3.4 °C. Qualitatively, these studies showed that GNR solutions are more effective photosensitizing agents than ICG solution.

Paper Details

Date Published: 21 March 2016
PDF: 6 pages
Proc. SPIE 9709, Biophotonics and Immune Responses XI, 97090A (21 March 2016); doi: 10.1117/12.2214631
Show Author Affiliations
Aamr M. Hasanjee, Univ. of Central Oklahoma (United States)
Feifan Zhou, Univ. of Central Oklahoma (United States)
Connor West, Univ. of Central Oklahoma (United States)
Kegan Silk, Univ. of Central Oklahoma (United States)
Austin Doughty, Univ. of Central Oklahoma (United States)
Cody F. Bahavar, Univ. of Central Oklahoma (United States)
Wei R. Chen, Univ. of Central Oklahoma (United States)


Published in SPIE Proceedings Vol. 9709:
Biophotonics and Immune Responses XI
Wei R. Chen, Editor(s)

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