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Proceedings Paper

A compact bio-inspired visible/NIR imager for image-guided surgery (Conference Presentation)
Author(s): Shengkui Gao; Missael Garcia; Chris Edmiston; Timothy York; Radoslav Marinov; Suman B. Mondal; Nan Zhu; Gail P. Sudlow; Walter J. Akers; Julie A. Margenthaler; Rongguang Liang; Marta Pepino; Samuel Achilefu; Viktor Gruev
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Paper Abstract

Inspired by the visual system of the morpho butterfly, we have designed, fabricated, tested and clinically translated an ultra-sensitive, light weight and compact imaging sensor capable of simultaneously capturing near infrared (NIR) and visible spectrum information. The visual system of the morpho butterfly combines photosensitive cells with spectral filters at the receptor level. The spectral filters are realized by alternating layers of high and low dielectric constant, such as air and cytoplasm. We have successfully mimicked this concept by integrating pixelated spectral filters, realized by alternating silicon dioxide and silicon nitrate layers, with an array of CCD detectors. There are four different types of pixelated spectral filters in the imaging plane: red, green, blue and NIR. The high optical density (OD) of all spectral filters (OD>4) allow for efficient rejections of photons from unwanted bands. The single imaging chip weighs 20 grams with form factor of 5mm by 5mm. The imaging camera is integrated with a goggle display system. A tumor targeted agent, LS301, is used to identify all spontaneous tumors in a transgenic PyMT murine model of breast cancer. The imaging system achieved sensitivity of 98% and selectivity of 95%. We also used our imaging sensor to locate sentinel lymph nodes (SLNs) in patients with breast cancer using indocyanine green tracer. The surgeon was able to identify 100% of SLNs when using our bio-inspired imaging system, compared to 93% when using information from the lymphotropic dye and 96% when using information from the radioactive tracer.

Paper Details

Date Published: 26 April 2016
PDF: 1 pages
Proc. SPIE 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II, 96960A (26 April 2016); doi: 10.1117/12.2214617
Show Author Affiliations
Shengkui Gao, Washington Univ. in St. Louis (United States)
Missael Garcia, Washington Univ. in St. Louis (United States)
Chris Edmiston, Washington Univ. in St. Louis (United States)
Timothy York, Southern Illinois Univ. Edwardsville (United States)
Radoslav Marinov, Washington Univ. in St. Louis (United States)
Suman B. Mondal, Washington Univ. in St. Louis (United States)
Nan Zhu, College of Optical Sciences, The Univ. of Arizona (United States)
Gail P. Sudlow, Washington Univ. School of Medicine in St. Louis (United States)
Walter J. Akers, Washington Univ. School of Medicine in St. Louis (United States)
Julie A. Margenthaler, Washington Univ. School of Medicine in St. Louis (United States)
Rongguang Liang, Washington Univ. in St. Louis (United States)
Marta Pepino, Washington Univ. in St. Louis (United States)
Samuel Achilefu, Washington Univ. School of Medicine in St. Louis (United States)
Viktor Gruev, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 9696:
Molecular-Guided Surgery: Molecules, Devices, and Applications II
Brian W. Pogue; Sylvain Gioux, Editor(s)

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