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Proceedings Paper

Development of a high-speed VCSEL OCT system for real-time imaging of conscious patients larynx using a hand-held probe (Conference Presentation)
Author(s): Swathi Rangarajan; Li-Dek Chou; Carolyn Coughlan; Giriraj Sharma; Brian J. F. Wong; Tirunelveli S. Ramalingam

Paper Abstract

Fourier domain optical coherence tomography (FD-OCT) is a noninvasive imaging modality that has previously been used to image the human larynx. However, differences in anatomical geometry and short imaging range of conventional OCT limits its application in a clinical setting. In order to address this issue, we have developed a gradient-index (GRIN) lens rod-based hand-held probe in conjunction with a long imaging range 200 kHz Vertical-Cavity Surface Emitting Lasers (VCSEL) swept-source optical coherence tomography (SS-OCT) system for high speed real-time imaging of the human larynx in an office setting. This hand-held probe is designed to have a long and dynamically tunable working distance to accommodate the differences in anatomical geometry of human test subjects. A nominal working distance (~6 cm) of the probe is selected to have a lateral resolution <100 um within a depth of focus of 6.4 mm, which covers more than half of the 12 mm imaging range of the VCSEL laser. The maximum lateral scanning range of the probe at 6 cm working distance is approximately 8.4 mm, and imaging an area of 8.5 mm by 8.5 mm is accomplished within a second. Using the above system, we will demonstrate real-time cross-sectional OCT imaging of larynx during phonation in vivo in human and ex-vivo in pig vocal folds.

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 968920 (27 April 2016); doi: 10.1117/12.2214403
Show Author Affiliations
Swathi Rangarajan, OCT Medical Imaging Inc. (United States)
Li-Dek Chou, OCT Medical Imaging Inc. (United States)
Beckman Laser Institute and Medical Clinic (United States)
Carolyn Coughlan, Univ. of California, Irvine (United States)
Giriraj Sharma, Univ. of California, Irvine (United States)
Brian J. F. Wong, Univ. of California, Irvine (United States)
Beckman Laser Institute and Medical Ctr. (United States)
Tirunelveli S. Ramalingam, OCT Medical Imaging Inc. (United States)

Published in SPIE Proceedings Vol. 9689:
Photonic Therapeutics and Diagnostics XII
Hyun Wook Kang; Guillermo J. Tearney; Melissa C. Skala; Bernard Choi; Andreas Mandelis; Brian J. F. Wong; Justus F. Ilgner; Nikiforos Kollias; Paul J. Campagnola; Kenton W. Gregory; Laura Marcu; Haishan Zeng, Editor(s)

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