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Proceedings Paper

Multimode optical dermoscopy (SkinSpect) analysis for skin with melanocytic nevus
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Paper Abstract

We have developed a multimode dermoscope (SkinSpect™) capable of illuminating human skin samples in-vivo with spectrally-programmable linearly-polarized light at 33 wavelengths between 468nm and 857 nm. Diffusely reflected photons are separated into collinear and cross-polarized image paths and images captured for each illumination wavelength. In vivo human skin nevi (N = 20) were evaluated with the multimode dermoscope and melanin and hemoglobin concentrations were compared with Spatially Modulated Quantitative Spectroscopy (SMoQS) measurements. Both systems show low correlation between their melanin and hemoglobin concentrations, demonstrating the ability of the SkinSpect™ to separate these molecular signatures and thus act as a biologically plausible device capable of early onset melanoma detection.

Paper Details

Date Published: 6 April 2016
PDF: 7 pages
Proc. SPIE 9711, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX, 971110 (6 April 2016); doi: 10.1117/12.2214288
Show Author Affiliations
Fartash Vasefi, Spectral Molecular Imaging, Inc. (United States)
Nicholas MacKinnon, Spectral Molecular Imaging, Inc. (United States)
Rolf Saager, Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine (United States)
Kristen M. Kelly, Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine (United States)
Tyler Maly, Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine (United States)
Robert Chave, Spectral Molecular Imaging, Inc. (United States)
Nicholas Booth, Spectral Molecular Imaging, Inc. (United States)
Anthony J. Durkin, Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine (United States)
Daniel L. Farkas, Spectral Molecular Imaging, Inc. (United States)
Univ. of Southern California (United States)


Published in SPIE Proceedings Vol. 9711:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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