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Proceedings Paper

Pancreas tumor interstitial pressure catheter measurement
Author(s): Michael D. Nieskoski; Jason Gunn; Kayla Marra; B. Stuart Trembly; Brian W. Pogue
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Paper Abstract

This paper highlights the methodology in measuring interstitial pressure in pancreatic adenocarcinoma tumors. A Millar Mikrotip pressure catheter (SPR-671) was used in this study and a system was built to amplify and filter the output signal for data collection. The Millar pressure catheter was calibrated prior to each experiment in a water column at 37°C, range of 0 to 60 inH2O (112 mmHg), resulting in a calibration factor of 33 mV / 1 inH2O. The interstitial pressures measured in two orthotopically grown pancreatic adenocarcinoma tumor were 57 mmHg and 48 mmHg, respectively. Verteporfin uptake into the pancreatic adenocarcinoma tumor was measured using a probe-based experimental dosimeter.

Paper Details

Date Published: 5 April 2016
PDF: 7 pages
Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 969408 (5 April 2016); doi: 10.1117/12.2214181
Show Author Affiliations
Michael D. Nieskoski, Thayer School of Engineering at Dartmouth (United States)
Jason Gunn, Thayer School of Engineering at Dartmouth (United States)
Kayla Marra, Thayer School of Engineering at Dartmouth (United States)
B. Stuart Trembly, Thayer School of Engineering at Dartmouth (United States)
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)


Published in SPIE Proceedings Vol. 9694:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV
David H. Kessel; Tayyaba Hasan, Editor(s)

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