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Proceedings Paper

High speed intravascular photoacoustic imaging of atherosclerotic arteries (Conference Presentation)

Paper Abstract

Cardiovascular disease is the leading cause of death in the industrialized nations. Accurate quantification of both the morphology and composition of lipid-rich vulnerable atherosclerotic plaque are essential for early detection and optimal treatment in clinics. In previous works, intravascular photoacoustic (IVPA) imaging for detection of lipid-rich plaque within coronary artery walls has been demonstrated in ex vivo, but the imaging speed is still limited. In order to increase the imaging speed, a high repetition rate laser is needed. In this work, we present a high speed integrated IVPA/US imaging system with a 500 Hz optical parametric oscillator laser at 1725 nm. A miniature catheter with 1.0 mm outer diameter was designed with a 200 μm multimode fiber and an ultrasound transducer with 45 MHz center frequency. The fiber was polished at 38 degree and enclosed in a glass capillary for total internal reflection. An optical/electrical rotary junction and pull-back mechanism was applied for rotating and linearly scanning the catheter to obtain three-dimensional imaging. Atherosclerotic rabbit abdominal aorta was imaged as two frame/second at 1725 nm. Furthermore, by wide tuning range of the laser wavelength from 1680 nm to 1770 nm, spectroscopic photoacoustic analysis of lipid-mimicking phantom and an human atherosclerotic artery was performed ex vivo. The results demonstrated that the developed IVPA/US imaging system is capable for high speed intravascular imaging for plaque detection.

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 968930 (27 April 2016); doi: 10.1117/12.2214068
Show Author Affiliations
Zhonglie Piao, Beckman Laser Institute and Medical Clinic (United States)
Pusan National Univ. (Korea, Republic of)
Teng Ma, The Univ. of Southern California (United States)
Yueqiao Qu, Beckman Laser Institute and Medical Clinic (United States)
Jiawen Li, Beckman Laser Institute and Medical Clinic (United States)
Mingyue Yu, The Univ. of Southern California (United States)
Youmin He, Beckman Laser Institute and Medical Clinic (United States)
K. Kirk Shung, The Univ. of Southern California (United States)
Qifa Zhou, The Univ. of Southern California (United States)
Chang-Seok Kim, Pusan National Univ. (Korea, Republic of)
Zhongping Chen, Beckman Laser Institute and Medical Clinic (United States)


Published in SPIE Proceedings Vol. 9689:
Photonic Therapeutics and Diagnostics XII
Hyun Wook Kang; Guillermo J. Tearney; Melissa C. Skala; Bernard Choi; Andreas Mandelis; Brian J. F. Wong; Justus F. Ilgner; Nikiforos Kollias; Paul J. Campagnola; Kenton W. Gregory; Laura Marcu; Haishan Zeng, Editor(s)

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