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Proceedings Paper

NIR fluorescent image-based evaluation of gastric tube perfusion after esophagectomy in preclinical model (Conference Presentation)
Author(s): Minji Kim; Yuhua Quan; Kook Nam Han; Byeong Hyun Choi; Yeonho Choi; Hyun Koo Kim; Beop-Min Kim
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Paper Abstract

This study was to evaluate the feasibility of near infrared (NIR) fluorescent images as a tool for evaluating the perfusion of the gastric tube after esophagectomy. In addition, we investigated the time required to acquire enough signal to confirm the presence of ischemia in gastric tube after injection of indocyanine green (ICG) through peripheral versus and central venous route. 4 porcine underwent esophagogastrostomy and their right gastric arteries were ligated to mimic ischemic condition of gastric tube. ICG (0.6mg/kg) was intravenously injected and the fluorescence signal-to-background ratios (SBR) were measured by using the custom-built intraoperative color and fluorescence imaging system (ICFIS). We evaluated perfusion of gastric tubes by comparing their SBR with esophageal SBR. In ischemic models, SBR of esophagus was higher than that of gastric tube (2.8±0.54 vs. 1.7±0.37, p<0.05). It showed high esophagus-stomach signal to signal ratio. (SSR, 1.8±0.76). We also could observe recovery of blood perfusion in few minutes after releasing the ligation of right gastric artery. In addition, in comparison study according to the injection route of ICG, The time to acquire signal stabilization was faster in central than in peripheral route (119 ± 65.1 seconds in central route vs. 295±130.4 in peripheral route, p<0.05). NIR fluorescent images could provide the real-time information if there was ischemia or not in gastric tube during operation. And, central injection of ICG might give that information faster than peripheral route.

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9698, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV, 96980C (27 April 2016); doi: 10.1117/12.2214064
Show Author Affiliations
Minji Kim, Korea Univ. (Korea, Republic of)
Yuhua Quan, Korea Univ. Guro Hospital (Korea, Republic of)
Kook Nam Han, Korea Univ. Guro Hospital (Korea, Republic of)
Byeong Hyun Choi, Korea Univ. Guro Hospital (Korea, Republic of)
Yeonho Choi, Korea Univ. Guro Hospital (Korea, Republic of)
Korea Univ. (Korea, Republic of)
Hyun Koo Kim, Korea Univ. Guro Hospital (Korea, Republic of)
Beop-Min Kim, Korea Univ. (Korea, Republic of)


Published in SPIE Proceedings Vol. 9698:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest, Editor(s)

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