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Proceedings Paper

Adapting biomodulatory strategies for treatment in new contexts: pancreatic and oral cancers (Conference Presentation)

Paper Abstract

Biomodulation of cancer cell metabolism represents a promising approach to overcome tumor heterogeneity and poor selectivity, which contribute significantly to treatment resistance. To date, several studies have demonstrated that modulation of cell metabolism including the heme synthesis pathway serves as an elegant approach to improve the efficacy of aminolevulinic acid (ALA) based photodynamic therapy (PDT). However, the ability of biomodulation-enhanced PDT to improve outcomes in low resource settings and to address challenges in treating lethal tumors with exogenous photosensitizers remains underexplored. The ability of vitamin D or methotrexate to enhance PDT efficacy in a carcinogen-induced hamster cheek pouch model of oral squamous cell carcinoma and in 3D cell-based models for pancreatic ductal adenocarcinoma is evaluated. Challenges associated with adapting PDT regimens to low resource settings, understanding the effects of biomodulatory agents on the metabolism of cancer cells, and the differential effects of biomodulatory agents on tumor and stromal cells will be discussed.

Paper Details

Date Published: 26 April 2016
PDF: 1 pages
Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 96940M (26 April 2016); doi: 10.1117/12.2213922
Show Author Affiliations
Sriram R. Anbil, Harvard Medical School (United States)
Howard Hughes Medical Institute (United States)
The Univ. of Texas Health Science Ctr. at San Antonio (United States)
Imran Rizvi, Brigham and Women's Hospital (United States)
Harvard Medical School (United States)
Amjad P. Khan, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Jonathan P. Celli, Univ. of Massachusetts Boston (United States)
Edward V. Maytin, Cleveland Clinic Lerner Research Institute (United States)
Tayyaba Hasan, Massachusetts General Hospital (United States)
Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 9694:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV
David H. Kessel; Tayyaba Hasan, Editor(s)

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