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Proceedings Paper

Intraoperative imaging using intravascular contrast agent
Author(s): Jeffrey R. Watson; Nikolay Martirosyan; Summer Garland; G. Michael Lemole; Marek Romanowski
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Paper Abstract

Near-infrared (NIR) contrast agents are becoming more frequently studied in medical imaging due to their advantageous characteristics, most notably the ability to capture near-infrared signal across the tissue and the safety of the technique. This produces a need for imaging technology that can be specific for both the NIR dye and medical application. Indocyanine green (ICG) is currently the primary NIR dye used in neurosurgery. Here we report on using the augmented microscope we described previously for image guidance in a rat glioma resection. Luc-C6 cells were implanted in a rat in the left-frontal lobe and grown for 22 days. Surgical resection was performed by a neurosurgeon using augmented microscopy guidance with ICG contrast. Videos and images were acquired to evaluate image quality and resection margins. ICG accumulated in the tumor tissue due to enhanced permeation and retention from the compromised bloodbrain- barrier. The augmented microscope was capable of guiding the rat glioma resection and intraoperatively highlighted tumor tissue regions via ICG fluorescence under normal illumination of the surgical field.

Paper Details

Date Published: 4 March 2016
PDF: 5 pages
Proc. SPIE 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II, 96960L (4 March 2016); doi: 10.1117/12.2213867
Show Author Affiliations
Jeffrey R. Watson, The Univ. of Arizona (United States)
Nikolay Martirosyan, Banner Univ. Medical Ctr. (United States)
Summer Garland, The Univ. of Arizona (United States)
G. Michael Lemole, Banner Univ. Medical Ctr. (United States)
Marek Romanowski, The Univ. of Arizona (United States)


Published in SPIE Proceedings Vol. 9696:
Molecular-Guided Surgery: Molecules, Devices, and Applications II
Brian W. Pogue; Sylvain Gioux, Editor(s)

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