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Proceedings Paper

In vivo detection of oral epithelial cancer using endogenous fluorescence lifetime imaging: a pilot human study (Conference Presentation)
Author(s): Javier A. Jo; Dae Yon Hwang; Jorge Palma; Shuna Cheng; Rodrigo Cuenca; Bilal Malik; Joey Jabbour; Lisa Cheng; John Wright; Kristen Maitland
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Paper Abstract

Endogenous fluorescence lifetime imaging (FLIM) provides direct access to the concomitant functional and biochemical changes accompanying tissue transition from benign to precancerous and cancerous. Since FLIM can noninvasively measure different and complementary biomarkers of precancer and cancer, we hypothesize that it will aid in clinically detecting early oral epithelial cancer. Our group has recently demonstrated the detection of benign from premalignant and malignant lesions based on endogenous multispectral FLIM in the hamster cheek-pouch model. Encouraged by these positive preliminary results, we have developed a handheld endoscope capable of acquiring multispectral FLIM images in real time from the oral mucosa. This novel FLIM endoscope is being used for imaging clinically suspicious pre-malignant and malignant lesions from patients before undergoing tissue biopsy for histopathological diagnosis of oral epithelial cancer. Our preliminary results thus far are already suggesting the potential of endogenous FLIM for distinguishing a variety of benign lesions from advanced dysplasia and squamous cell carcinoma (SCC). To the best of out knowledge, this is the first in vivo human study aiming to demonstrate the ability to predict the true malignancy of clinically suspicious lesions using endogenous FLIM. If successful, the resulting clinical tool will allow noninvasive real-time detection of epithelial precancerous and cancerous lesions in the oral mucosa and could potentially be used to assist at every step involved on the clinical management of oral cancer patients, from early screening and diagnosis, to treatment and monitoring of recurrence.

Paper Details

Date Published: 3 May 2016
PDF: 1 pages
Proc. SPIE 9698, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV, 969805 (3 May 2016); doi: 10.1117/12.2213846
Show Author Affiliations
Javier A. Jo, Texas A&M Univ. (United States)
Dae Yon Hwang, Texas A&M Univ. (United States)
Jorge Palma, Texas A&M Univ. (United States)
Shuna Cheng, Texas A&M Univ. (United States)
Rodrigo Cuenca, Texas A&M Univ. (United States)
Bilal Malik, Texas A&M Univ. (United States)
Joey Jabbour, Texas A&M Univ. (United States)
Lisa Cheng, Texas A&M Univ. (United States)
John Wright, Texas A&M Univ. (United States)
Kristen Maitland, Texas A&M Univ. (United States)


Published in SPIE Proceedings Vol. 9698:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest M.D., Editor(s)

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