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Proceedings Paper

Localized biomolecules immobilization in optical microbubble resonators
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Paper Abstract

In order to optimize the performance of an optical microbubble resonator (OMBR) as biosensor, the chemical functionalization of its inner surface plays a key role. Here we report on a spatially selective photo – chemical procedure able to bind fluorescent biomolecules only in correspondence of the OMBR inner surface. This abruptly reduces the occurrence of an undesired specific biochemical bond event all along the microfluidic section of the device. The evidence of this method, which maintains high Q factor (> 105) for the OMBR in buffer solution, is proved by fluorescence microscopy and real time measurement of the resonance broadening.

Paper Details

Date Published: 22 April 2016
PDF: 8 pages
Proc. SPIE 9727, Laser Resonators, Microresonators, and Beam Control XVIII, 972719 (22 April 2016); doi: 10.1117/12.2213683
Show Author Affiliations
S. Berneschi, Istituto di Fisica Applicata "Nello Carrara" (Italy)
F. Baldini, Istituto di Fisica Applicata "Nello Carrara" (Italy)
A. Barucci, Istituto di Fisica Applicata "Nello Carrara" (Italy)
A. Cosci, Museo Storico della Fisica e Ctr. Studi e Ricerche "Enrico Fermi" (Italy)
Istituto di Fisica Applicata "Nello Carrara" (Italy)
F. Cosi, Istituto di Fisica Applicata "Nello Carrara" (Italy)
D. Farnesi, Museo Storico della Fisica e Ctr. Studi e Ricerche "Enrico Fermi" (Italy)
Istituto di Fisica Applicata "Nello Carrara" (Italy)
G. Nunzi Conti, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Museo Storico della Fisica e Ctr. Studi e Ricerche "Enrico Fermi" (Italy)
G. C. Righini, Museo Storico della Fisica e Ctr. Studi e Ricerche "Enrico Fermi" (Italy)
Istituto di Fisica Applicata "Nello Carrara" (Italy)
S. Soria, Istituto di Fisica Applicata "Nello Carrara" (Italy)
S. Tombelli, Istituto di Fisica Applicata "Nello Carrara" (Italy)
C. Trono, Istituto di Fisica Applicata "Nello Carrara" (Italy)
S. Pelli, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Museo Storico della Fisica e Ctr. Studi e Ricerche "Enrico Fermi" (Italy)
A. Giannetti, Istituto di Fisica Applicata "Nello Carrara" (Italy)


Published in SPIE Proceedings Vol. 9727:
Laser Resonators, Microresonators, and Beam Control XVIII
Alexis V. Kudryashov; Alan H. Paxton; Vladimir S. Ilchenko, Editor(s)

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