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Proceedings Paper

Thumb-size ultrasonic-assisted spectroscopic imager for in-situ glucose monitoring as optional sensor of conventional dialyzers
Author(s): Kosuke Nogo; Keita Mori; Wei Qi; Satsuki Hosono; Natsumi Kawashima; Akira Nishiyama; Kenji Wada; Ichiro Ishimaru
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Paper Abstract

We proposed the ultrasonic-assisted spectroscopic imaging for the realization of blood-glucose-level monitoring during dialytic therapy. Optical scattering and absorption caused by blood cells deteriorate the detection accuracy of glucose dissolved in plasma. Ultrasonic standing waves can agglomerate blood cells at nodes. In contrast, around anti-node regions, the amount of transmitted light increases because relatively clear plasma appears due to decline the number of blood cells. Proposed method can disperse the transmitted light of plasma without time-consuming pretreatment such as centrifugation. To realize the thumb-size glucose sensor which can be easily attached to dialysis tubes, an ultrasonic standing wave generator and a spectroscopic imager are required to be small. Ultrasonic oscillators are ∅30[mm]. A drive circuit of oscillators, which now size is 41×55×45[mm], is expected to become small. The trial apparatus of proposed one-shot Fourier spectroscopic imager, whose size is 30×30×48[mm], also can be little-finger size in principal. In the experiment, we separated the suspension mixed water and micro spheres (Θ10[mm) into particles and liquid regions with the ultrasonic standing wave (frequency: 2[MHz]). Furthermore, the spectrum of transmitted light through the suspension could be obtained in visible light regions with a white LED.

Paper Details

Date Published: 7 March 2016
PDF: 4 pages
Proc. SPIE 9699, Optics and Biophotonics in Low-Resource Settings II, 96990N (7 March 2016); doi: 10.1117/12.2213629
Show Author Affiliations
Kosuke Nogo, Kagawa Univ. (Japan)
Keita Mori, Kagawa Univ. (Japan)
Wei Qi, Kagawa Univ. (Japan)
Satsuki Hosono, Kagawa Univ. (Japan)
Natsumi Kawashima, Kagawa Univ. (Japan)
Akira Nishiyama, Kagawa Univ. (Japan)
Kenji Wada, Kagawa Univ. (Japan)
Ichiro Ishimaru, Kagawa Univ. (Japan)

Published in SPIE Proceedings Vol. 9699:
Optics and Biophotonics in Low-Resource Settings II
David Levitz; Aydogan Ozcan; David Erickson, Editor(s)

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