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Proceedings Paper

Tract specific analysis in patients with sickle cell disease
Author(s): Yaqiong Chai; Julie Coloigner; Xiaoping Qu; Soyoung Choi; Adam Bush; Matt Borzage; Chau Vu; Natasha Lepore; John Wood
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Paper Abstract

Sickle cell disease (SCD) is a hereditary blood disorder in which the oxygen-carrying hemoglobin molecule in red blood cells is abnormal. It affects numerous people in the world and leads to a shorter life span, pain, anemia, serious infections and neurocognitive decline. Tract-Specific Analysis (TSA) is a statistical method to evaluate white matter alterations due to neurocognitive diseases, using diffusion tensor magnetic resonance images. Here, for the first time, TSA is used to compare 11 major brain white matter (WM) tracts between SCD patients and age-matched healthy subjects. Alterations are found in the corpus callosum (CC), the cortico-spinal tract (CST), inferior fronto-occipital fasciculus (IFO), inferior longitudinal fasciculus (ILF), superior longitudinal fasciculus (SLF), and uncinated fasciculus (UNC). Based on previous studies on the neurocognitive functions of these tracts, the significant areas found in this paper might be related to several cognitive impairments and depression, both of which are observed in SCD patients.

Paper Details

Date Published: 22 December 2015
PDF: 6 pages
Proc. SPIE 9681, 11th International Symposium on Medical Information Processing and Analysis, 968108 (22 December 2015); doi: 10.1117/12.2213617
Show Author Affiliations
Yaqiong Chai, Children's Hospital Los Angeles (United States)
Univ. of Southern California (United States)
Julie Coloigner, Children's Hospital Los Angeles (United States)
Xiaoping Qu, Children's Hospital Los Angeles (United States)
Univ. of Southern California (United States)
Soyoung Choi, Children's Hospital Los Angeles (United States)
Adam Bush, Children's Hospital Los Angeles (United States)
Univ. of Southern California (United States)
Matt Borzage, Children's Hospital Los Angeles (United States)
Chau Vu, Children's Hospital Los Angeles (United States)
Natasha Lepore, Children's Hospital Los Angeles (United States)
Univ. of Southern California (United States)
John Wood, Children's Hospital Los Angeles (United States)


Published in SPIE Proceedings Vol. 9681:
11th International Symposium on Medical Information Processing and Analysis
Eduardo Romero; Natasha Lepore; Juan D. García-Arteaga; Jorge Brieva, Editor(s)

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