Share Email Print
cover

Proceedings Paper

Brillouin spectroscopy of clotting dynamics in a model system
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Keys to successful treatment of disease include early diagnosis and timely treatment. It is hypothesized that early clotting events may contribute to a pro-thrombotic state that exacerbates atherothrombotic vascular disease. Brillouin spectroscopy involves inelastic coupling of light with phonons and enables viscoelastic characterization of samples at the microscale. In this work, we apply Brillouin spectroscopy to a model fibrinogen-thrombin clotting system with the goal of measuring clotting dynamics at the microscale and providing characterization that is not possible with standard rheometric techniques. Here, the clotting dynamics of the model clotting system are measured at various fibrinogen and thrombin concentrations.

Paper Details

Date Published: 14 April 2016
PDF: 6 pages
Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96892T (14 April 2016); doi: 10.1117/12.2213595
Show Author Affiliations
Sandra C. Bustamante-Lopez, Swansea Univ. (United Kingdom)
Texas A&M Univ. (United Kingdom)
Andrew J. Traverso, Texas A&M Univ. (United States)
Vladislav V. Yakovlev, Texas A&M Univ. (United States)
Kenith E. Meissner, Swansea Univ. (United Kingdom)


Published in SPIE Proceedings Vol. 9689:
Photonic Therapeutics and Diagnostics XII
Hyun Wook Kang; Guillermo J. Tearney; Melissa C. Skala; Bernard Choi; Andreas Mandelis; Brian J. F. Wong; Justus F. Ilgner; Nikiforos Kollias; Paul J. Campagnola; Kenton W. Gregory; Laura Marcu; Haishan Zeng, Editor(s)

© SPIE. Terms of Use
Back to Top