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Proceedings Paper

Phase-sensitive multiple reference optical coherence tomography (Conference Presentation)
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Paper Abstract

Multiple reference OCT (MR-OCT) is a recently developed novel time-domain OCT platform based on a miniature reference arm optical delay, which utilizes a single miniature actuator and a partial mirror to generate recirculating optical delay for extended axial-scan range. MR-OCT technology promises to fit into a robust and cost-effective design, compatible with integration into consumer-level devices for addressing wide applications in mobile healthcare and biometry applications. Using conventional intensity based OCT processing techniques, the high-resolution structural imaging capability of MR-OCT has been recently demonstrated for various applications including in vivo human samples. In this study, we demonstrate the feasibility of implementing phase based processing with MR-OCT for various functional applications such as Doppler imaging and sensing of blood vessels, and for tissue vibrography applications. The MR-OCT system operates at 1310nm with a spatial resolution of ~26 µm and an axial scan rate of 600Hz. Initial studies show a displacement-sensitivity of ~20 nm to ~120 nm for the first 1 to 9 orders of reflections, respectively with a mirror as test-sample. The corresponding minimum resolvable velocity for these orders are ~2.3 µm/sec and ~15 µm/sec respectively. Data from a chick chorioallantoic membrane (CAM) model will be shown to demonstrate the feasibility of MR-OCT for imaging in-vivo blood flow.

Paper Details

Date Published: 3 May 2016
PDF: 1 pages
Proc. SPIE 9699, Optics and Biophotonics in Low-Resource Settings II, 96990O (3 May 2016); doi: 10.1117/12.2213574
Show Author Affiliations
Roshan I. Dsouza, National Univ. of Ireland, Galway (Ireland)
Hrebesh Subhash, National Univ. of Ireland, Galway (Ireland)
Kai Neuhaus, National Univ. of Ireland, Galway (Ireland)
Josh Hogan, Compact Imaging, Inc. (United States)
Carol Wilson, Compact Imaging, Inc. (United States)
Martin Leahy, National Univ. of Ireland, Galway (Ireland)

Published in SPIE Proceedings Vol. 9699:
Optics and Biophotonics in Low-Resource Settings II
David Levitz; Aydogan Ozcan; David Erickson, Editor(s)

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