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Proceedings Paper

Designing PDT-based combinations to overcome chemoresistance in heterocellular 3D tumor models (Conference Presentation)
Author(s): Imran Rizvi; Emma A. Briars; Anne-Laure Bulin; Sriram Anbil; Daniela Vecchio; Ahmed Alkhateeb; William R. Hanna; Jonathan P. Celli; Tayyaba Hasan
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Paper Abstract

A major barrier to treating advanced-stage cancers is heterogeneity in the responsiveness of metastatic disease to conventional therapies leading to resistance and treatment failure. Photodynamic therapy (PDT) has been shown to synergize with conventional agents and to overcome the evasion pathways that cause resistance. Developing PDT-based combinations that target resistant tumor populations and cooperate mechanistically with conventional agents is an increasingly promising approach to improve therapeutic efficacy while minimizing toxicity, particularly in complex disease sites. Identifying the molecular, cellular, and microenvironmental cues that lead to heterogeneity and treatment resistance is critical to developing strategies to target unresponsive regions of stubborn disease. Cell-based research platforms that integrate key microenvironmental cues are emerging as increasingly important tools to improve the translational efficiency of new agents, and to design combination regimens. Among the challenges associated with developing and scaling complex cell-based screening platforms is the need to integrate, and balance, biological relevance with appropriate, high-content imaging routines that provide meaningful quantitative readouts of therapeutic response. The benefits and challenges associated with deriving meaningful insights from complex cell-based models will be presented, with a particular emphasis on overcoming chemoresistance mediated by physical stress and communication with stromal partners (e.g. tumor endothelial cells, which are emerging as dynamic regulators of treatment resistance) using PDT-based combinations.

Paper Details

Date Published: 26 April 2016
PDF: 1 pages
Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 969404 (26 April 2016); doi: 10.1117/12.2213436
Show Author Affiliations
Imran Rizvi, Brigham and Women's Hospital (United States)
Harvard Medical School (United States)
Emma A. Briars, Massachusetts General Hospital (United States)
Wellman Ctr. for Photomedicine (United States)
Anne-Laure Bulin, Wellman Ctr. for Photomedicine (United States)
Harvard Medical School (United States)
Sriram Anbil, Wellman Ctr. for Photomedicine (United States)
Howard Hughes Medical Institute (United States)
Daniela Vecchio, Wellman Center for Photomedicine, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Ahmed Alkhateeb, Wellman Ctr. for Photomedicine (United States)
Harvard Medical School (United States)
William R. Hanna, Univ. of Massachusetts Boston (United States)
Jonathan P. Celli, Univ. of Massachusetts Boston (United States)
Tayyaba Hasan, Wellman Ctr. for Photomedicine (United States)
Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 9694:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV
David H. Kessel; Tayyaba Hasan, Editor(s)

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