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Proceedings Paper

PDT dose dosimeter for pleural photodynamic therapy
Author(s): Michele M. Kim; Arash Darafsheh; Mahmoud Ahmad; Jarod C. Finlay; Timothy C. Zhu
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Paper Abstract

PDT dose is the product of the photosensitizer concentration and the light fluence in the target tissue. For improved dosimetry during plural photodynamic therapy (PDT), a PDT dose dosimeter was developed to measure both the light fluence and the photosensitizer concentration simultaneously in the same treatment location. Light fluence and spectral data were rigorously compared to other methods of measurement (e.g. photodiode, multi-fiber spectroscopy contact probe) to assess the accuracy of the measurements as well as their uncertainty. Photosensitizer concentration was obtained by measuring the fluorescence of the sensitizer excited by the treatment light. Fluence rate based on the intensity of the laser spectrum was compared to the data obtained by direct measurement of fluence rate by a fiber-coupled photodiode. Phantom studies were done to obtain an optical property correction for the fluorescence signal. Measurements were performed in patients treated Photofrin for different locations in the pleural cavity. Multiple sites were measured to investigate the heterogeneity of the cavity and to provide cross-validation via relative dosimetry. This novel method will allow for accurate real-time determination of delivered PDT dose and improved PDT dosimetry.

Paper Details

Date Published: 17 March 2016
PDF: 6 pages
Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 96940Y (17 March 2016); doi: 10.1117/12.2213401
Show Author Affiliations
Michele M. Kim, The Univ. of Pennsylvania Health System (United States)
Univ. of Pennsylvania (United States)
Arash Darafsheh, The Univ. of Pennsylvania Health System (United States)
Mahmoud Ahmad, The Univ. of Pennsylvania Health System (United States)
Jarod C. Finlay, The Univ. of Pennsylvania Health System (United States)
Timothy C. Zhu, The Univ. of Pennsylvania Health System (United States)


Published in SPIE Proceedings Vol. 9694:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV
David H. Kessel; Tayyaba Hasan, Editor(s)

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