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Proceedings Paper

Fluorescence and optical-resolution photoacoustic imaging through capillary waveguides
Author(s): Nicolino Stasio; Atsushi Shibukawa; Ioannis N. Papadopoulos; Salma Farahi; Olivier Simandoux; Jean-Pierre Huignard; Emmanuel Bossy; Christophe Moser; Demetri Psaltis
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Paper Abstract

Endoscopy can be used to obtain high-resolution images at large depths in biological tissues. Usually endoscopic devices have a diameter ranging from 1 to few millimeters. Using digital phase conjugation, it is possible to adapt ultrathin multimode fibers to endoscopic purposes. Recently, we demonstrated that a 330 μm diameter, water-filled silica capillary waveguide can guide high frequency ultrasound waves through a 3 cm thick fat layer, allowing optical resolution photoacoustic imaging. Here we demonstrate that using digital phase conjugation, the same water-filled capillary waveguide (3 cm long) can be used as an endoscopic probe to obtain both fluorescence and optical resolution photoacoustic imaging, with no optical or acoustic elements at the tip of the waveguide. We study the consequences of using digital phase conjugation combined with a capillary waveguide and we conclude with possible future improvements of our endoscopic approach.

Paper Details

Date Published: 15 March 2016
PDF: 8 pages
Proc. SPIE 9717, Adaptive Optics and Wavefront Control for Biological Systems II, 97171H (15 March 2016); doi: 10.1117/12.2213303
Show Author Affiliations
Nicolino Stasio, École Polytechnique Fédérale de Lausanne (Switzerland)
Atsushi Shibukawa, École Polytechnique Fédérale de Lausanne (Switzerland)
Ioannis N. Papadopoulos, École Polytechnique Fédérale de Lausanne (Switzerland)
Salma Farahi, École Polytechnique Fédérale de Lausanne (Switzerland)
Olivier Simandoux, ESPCI ParisTech, PSL Research Univ., CNRS, INSERM, Institut Langevin (France)
Jean-Pierre Huignard, Jphopto (France)
Emmanuel Bossy, École Polytechnique Fédérale de Lausanne (Switzerland)
ESPCI ParisTech, PSL Research Univ., CNRS, INSERM, Institut Langevin (France)
Christophe Moser, École Polytechnique Fédérale de Lausanne (Switzerland)
Demetri Psaltis, École Polytechnique Fédérale de Lausanne (Switzerland)


Published in SPIE Proceedings Vol. 9717:
Adaptive Optics and Wavefront Control for Biological Systems II
Thomas G. Bifano; Joel Kubby; Sylvain Gigan, Editor(s)

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