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Proceedings Paper

Abnormal ventricular development in preterm neonates with visually normal MRIs
Author(s): Jie Shi; Yalin Wang; Yi Lao; Rafael Ceschin; Liang Mi; Marvin D. Nelson; Ashok Panigrahy; Natasha Leporé
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Paper Abstract

Children born preterm are at risk for a wide range of neurocognitive and neurobehavioral disorders. Some of these may stem from early brain abnormalities at the neonatal age. Hence, a precise characterization of neonatal neuroanatomy may help inform treatment strategies. In particular, the ventricles are often enlarged in neurocognitive disorders, due to atrophy of surrounding tissues. Here we present a new pipeline for the detection of morphological and relative pose differences in the ventricles of premature neonates compared to controls. To this end, we use a new hyperbolic Ricci flow based mapping of the ventricular surfaces of each subjects to the Poincaré disk. Resulting surfaces are then registered to a template, and a between group comparison is performed using multivariate tensor-based morphometry. We also statistically compare the relative pose of the ventricles within the brain between the two groups, by performing a Procrustes alignment between each subject's ventricles and an average shape. For both types of analyses, differences were found in the left ventricles between the two groups.

Paper Details

Date Published: 22 December 2015
PDF: 8 pages
Proc. SPIE 9681, 11th International Symposium on Medical Information Processing and Analysis, 96810H (22 December 2015); doi: 10.1117/12.2213297
Show Author Affiliations
Jie Shi, Arizona State Univ. (United States)
Yalin Wang, Arizona State Univ. (United States)
Yi Lao, Univ. of Southern California (United States)
Children's Hospital Los Angeles (United States)
Rafael Ceschin, Children's Hospital of Pittsburgh UPMC (United States)
Liang Mi, Arizona State Univ. (United States)
Marvin D. Nelson, Children's Hospital Los Angeles (United States)
Univ. of Southern California (United States)
Ashok Panigrahy, Children's Hospital of Pittsburgh UPMC (United States)
Children's Hospital Los Angeles (United States)
Natasha Leporé, Univ. of Southern California (United States)
Children's Hospital Los Angeles (United States)


Published in SPIE Proceedings Vol. 9681:
11th International Symposium on Medical Information Processing and Analysis
Eduardo Romero; Natasha Lepore; Juan D. García-Arteaga; Jorge Brieva, Editor(s)

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