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Proceedings Paper

Corneal elastic anisotropy and hysteresis as a function of IOP assessed by optical coherence elastography
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Paper Abstract

The mechanical anisotropic properties of the cornea can be an important indicator for determining the onset and severity of different diseases and can be used to assess the efficacy of various therapeutic interventions, such as cross-linking and LASIK surgery. In this work, we introduce a noncontact method of assessing corneal mechanical anisotropy as a function of intraocular pressure (IOP) using optical coherence elastography (OCE). A focused air-pulse induced low amplitude (<10 μm) elastic waves in fresh porcine corneas in the whole eye-globe configuration in situ. A phase-stabilized swept source optical coherence elastography (PhS-SSOCE) system imaged the elastic wave propagation at stepped radial angles, and the OCE measurements were repeated as the IOP was cycled. The elastic wave velocity was then quantified to determine the mechanical anisotropy and hysteresis of the cornea. The results show that the elastic anisotropy at the corneal of the apex of the cornea becomes more pronounced at higher IOPs, and that there are distinct radial angles of higher and lower stiffness. Due to the noncontact nature and small amplitude of the elastic wave, this method may be useful for characterizing the elastic anisotropy of ocular and other tissues in vivo completely noninvasively.

Paper Details

Date Published: 8 March 2016
PDF: 7 pages
Proc. SPIE 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, 96971N (8 March 2016); doi: 10.1117/12.2213226
Show Author Affiliations
Jiasong Li, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Zhaolong Han, Univ. of Houston (United States)
Chen Wu, Univ. of Houston (United States)
Raksha Raghunathan, Univ. of Houston (United States)
Chih-Hao Liu, Univ. of Houston (United States)
Achuth Nair, Univ. of Houston (United States)
Shezaan Noorani, Univ. of Houston (United States)
Salavat R. Aglyamov, Univ. of Texas at Austin (United States)
Michael D. Twa, Univ. of Alabama at Birmingham (United States)
Kirill V. Larin, Univ. of Houston (United States)
Tomsk State Univ. (Russian Federation)
Baylor College of Medicine (United States)

Published in SPIE Proceedings Vol. 9697:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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