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Proceedings Paper

Swept-source anatomic optical coherence elastography of porcine trachea
Author(s): Ruofei Bu; Hillel Price; Sorin Mitran; Carlton Zdanski; Amy L. Oldenburg
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Paper Abstract

Quantitative endoscopic imaging is at the vanguard of novel techniques in the assessment upper airway obstruction. Anatomic optical coherence tomography (aOCT) has the potential to provide the geometry of the airway lumen with high-resolution and in 4 dimensions. By coupling aOCT with measurements of pressure, optical coherence elastography (OCE) can be performed to characterize airway wall stiffness. This can aid in identifying regions of dynamic collapse as well as informing computational fluid dynamics modeling to aid in surgical decision-making. Toward this end, here we report on an anatomic optical coherence tomography (aOCT) system powered by a wavelength-swept laser source. The system employs a fiber-optic catheter with outer diameter of 0.82 mm deployed via the bore of a commercial, flexible bronchoscope. Helical scans are performed to measure the airway geometry and to quantify the cross-sectional-area (CSA) of the airway. We report on a preliminary validation of aOCT for elastography, in which aOCT-derived CSA was obtained as a function of pressure to estimate airway wall compliance. Experiments performed on a Latex rubber tube resulted in a compliance measurement of 0.68±0.02 mm2/cmH2O, with R2=0.98 over the pressure range from 10 to 40 cmH2O. Next, ex vivo porcine trachea was studied, resulting in a measured compliance from 1.06±0.12 to 3.34±0.44 mm2/cmH2O, (R2>0.81). The linearity of the data confirms the elastic nature of the airway. The compliance values are within the same order-of-magnitude as previous measurements of human upper airways, suggesting that this system is capable of assessing airway wall compliance in future human studies.

Paper Details

Date Published: 8 March 2016
PDF: 9 pages
Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 968923 (8 March 2016); doi: 10.1117/12.2213186
Show Author Affiliations
Ruofei Bu, The Univ. of North Carolina at Chapel Hill (United States)
Hillel Price, The Univ. of North Carolina at Chapel Hill (United States)
Sorin Mitran, The Univ. of North Carolina at Chapel Hill (United States)
Carlton Zdanski, The Univ. of North Carolina at Chapel Hill (United States)
Amy L. Oldenburg, The Univ. of North Carolina at Chapel Hill (United States)

Published in SPIE Proceedings Vol. 9689:
Photonic Therapeutics and Diagnostics XII
Hyun Wook Kang; Guillermo J. Tearney; Melissa C. Skala; Bernard Choi; Andreas Mandelis; Brian J. F. Wong; Justus F. Ilgner; Nikiforos Kollias; Paul J. Campagnola; Kenton W. Gregory; Laura Marcu; Haishan Zeng, Editor(s)

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