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Proceedings Paper

Wide field OCT based microangiography in living human eye (Conference Presentation)
Author(s): Qinqin Zhang; Chieh-Li Chen; Zhongdi Chu; Anqi Zhang; Lin An; Mary Durbin; Utkarsh Sharma; Philip J. Rosenfeld; Ruikang K. Wang
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Paper Abstract

To investigate the application of optical microangiography (OMAG) in living human eye. Patients with different macular diseases were recruited, including diabetic retinopathy (DR), geographic atrophy (GA), retinitis pigmentosa (RP), and venous occlusion, et al. Wide field OCT angiography images can be generated by montage scanning protocol based on the tracking system. OMAG algorithm based on complex differentiation was used to extract the blood flow and removed the bulk motion by 2D cross-correlation method. The 3D angiography was segmented into 3 layers in the retina and 2 layers in the choroid. The en-face maximum projection was used to obtain 2-dimensional angiograms of different layers coded with different colors. Flow and structure images were combined for cross-sectional view. En face OMAG images of different macular diseases showed a great agreement with FA. Meanwhile, OMAG gave more distinct vascular network visions that were less affected by hemorrhage and leakage. The MAs were observed in both superficial and middle retinal layers based on OMAG angiograms in different layers of DR patients. The contour line of FAZ was extracted as well, which can be quantitative the retinal diseases. For GA patient, the damage of RPE layer enhanced the penetration of light and enabled the acquisition of choriocapillaries and choroidal vessels. The wide field OMAG angiogram enabled the capability of capturing the entire geographic atrophy. OMAG provides depth-resolved information and detailed vascular images of DR and GA patients, providing a better visualization of vascular network compared to FA.

Paper Details

Date Published: 26 April 2016
PDF: 1 pages
Proc. SPIE 9693, Ophthalmic Technologies XXVI, 969303 (26 April 2016); doi: 10.1117/12.2213097
Show Author Affiliations
Qinqin Zhang, Univ. of Washington (United States)
Chieh-Li Chen, Univ. of Washington (United States)
Zhongdi Chu, Univ. of Washington (United States)
Anqi Zhang, Univ. of Washington (United States)
Lin An, Carl Zeiss Meditec, Inc. (United States)
Mary Durbin, Carl Zeiss Meditec, Inc. (United States)
Utkarsh Sharma, Carl Zeiss Meditec, Inc. (United States)
Philip J. Rosenfeld, Bascom Palmer Eye Institute, Univ. of Miami (United States)
Ruikang K. Wang, Univ. of Washington (United States)

Published in SPIE Proceedings Vol. 9693:
Ophthalmic Technologies XXVI
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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