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Proceedings Paper

An improved analytic function for predicting light fluence rate in circular fields on a semi-infinite geometry
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Paper Abstract

Accurate determination of in-vivo light fluence rate is critical for preclinical and clinical studies involving photodynamic therapy (PDT). This study compares the longitudinal light fluence distribution inside biological tissue in the central axis of a 1 cm diameter circular uniform light field for a range of in-vivo tissue optical properties (absorption coefficients (μa) between 0.01 and 1 cm-1 and reduced scattering coefficients (μs’) between 2 and 40 cm-1). This was done using Monte-Carlo simulations for a semi-infinite turbid medium in an air-tissue interface. The end goal is to develop an analytical expression that would fit the results from the Monte Carlo simulation for both the 1 cm diameter circular beam and the broad beam. Each of these parameters is expressed as a function of tissue optical properties. These results can then be compared against the existing expressions in the literature for broad beam for analysis in both accuracy and applicable range. Using the 6-parameter model, the range and accuracy for light transport through biological tissue is improved and may be used in the future as a guide in PDT for light fluence distribution for known tissue optical properties.

Paper Details

Date Published: 7 March 2016
PDF: 9 pages
Proc. SPIE 9706, Optical Interactions with Tissue and Cells XXVII, 97061D (7 March 2016); doi: 10.1117/12.2213052
Show Author Affiliations
Timothy C. Zhu, Univ. of Pennsylvania (United States)
Amy Lu, Univ. of Pennsylvania (United States)
Yi-Hong Ong, Univ. of Pennsylvania (United States)

Published in SPIE Proceedings Vol. 9706:
Optical Interactions with Tissue and Cells XXVII
E. Duco Jansen, Editor(s)

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