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Proceedings Paper

Detection of particle flow patterns in tumor by directional spatial frequency analysis
Author(s): Stewart Russell; Hawa Camara; Lingyan Shi; P. Jack Hoopes; Peter Kaufman; Brian Pogue; Robert Alfano
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Paper Abstract

Drug delivery to tumors is well known to be chaotic and limited, partly from dysfunctional vasculature, but also because of microscopic regional variations in composition. Modeling the of transport of nanoparticle therapeutics, therefore must include not only a description of vascular permeability, but also of the movement of the drug as suspended in tumor interstitial fluid (TIF) once it leaves the blood vessel. Understanding of this area is limited because we currently lack the tools and analytical methods to characterize it. We have previously shown that directional anisotropy of drug delivery can be detected using Directional Fourier Spatial Frequency (DFSF) Analysis. Here we extend this approach to generate flow line maps of nanoparticle transport in TIF relative to tumor ultrastructure, and show that features of tumor spatial heterogeneity can be identified that are directly related to local flow isometries. The identification of these regions of limited flow may be used as a metric for determining response to therapy, or for the optimization of adjuvant therapies such as radiation pre-treatment, or enzymatic degradation.

Paper Details

Date Published: 7 April 2016
PDF: 5 pages
Proc. SPIE 9711, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX, 971109 (7 April 2016); doi: 10.1117/12.2213031
Show Author Affiliations
Stewart Russell, The City College of New York (United States)
Dartmouth College (United States)
Hawa Camara, The City College of New York (United States)
Lingyan Shi, The City College of New York (United States)
P. Jack Hoopes, Dartmouth Hitchcock Medical Ctr., Dartmouth College (United States)
Peter Kaufman, Dartmouth Hitchcock Medical Ctr., Dartmouth College (United States)
Brian Pogue, Dartmouth College (United States)
Robert Alfano, The City College of New York (United States)


Published in SPIE Proceedings Vol. 9711:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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