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Proceedings Paper

Chromatic multifocal pupillometer for objective perimetry in patients with macular degeneration (Conference Presentation)
Author(s): Ygal Rotenstreich; Daniel Ben-Ner; Mohamad Mahajna; Ron Chibel; Ifat Sher
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Paper Abstract

Purpose: To objectively assess visual field (VF) defects and retinal cell function in healthy subjects and patients with macular degeneration using a chromatic multifocal pupillometer. Methods: A multifocal chromatic pupillometer (MCP) was used to record pupillary responses (PR) of 17 healthy subjects and 5 Best Vitelliform macular dystrophy patients. Blue and red light stimuli (peak 485nm and 620nm, respectively) were presented at light intensities of 400 and 1000 cd/m2, respectively at 76 different points in a 16.2 degree VF. The PR of patients were compared with their findings on Humphrey's 24-2 perimetry, optical coherence tomography and the PR obtained from healthy subjects. Results: Patients demonstrated reduced percentage of pupillary contraction and slower maximal contraction velocity, more than two standard errors (SE) away from the mean of healthy subjects in response to red light in majority of VF locations. In response to blue light, the percentage of pupillary contraction was lower (by over two SE) compared with normal controls only in central locations. The latency of maximal contraction velocity was shorter in patients compared with healthy subjects in response to both colors. Conclusions: This study demonstrated the advantage of using MCP-based objective VF to assess central scotoma in macular degeneration. Our finding also suggests that chromatic perimetry may differentiate between PR mediated by cones and rods, and can specifically detect defects in macular cones. Different parameters of PR such as latency of maximal contraction velocity may shed light on the pathophysiology of different blinding diseases.

Paper Details

Date Published: 26 April 2016
PDF: 1 pages
Proc. SPIE 9693, Ophthalmic Technologies XXVI, 969313 (26 April 2016); doi: 10.1117/12.2212966
Show Author Affiliations
Ygal Rotenstreich, The Chaim Sheba Medical Ctr. (Israel)
Daniel Ben-Ner, The Chaim Sheba Medical Ctr. (Israel)
Mohamad Mahajna, The Chaim Sheba Medical Ctr. (Israel)
Ron Chibel, The Chaim Sheba Medical Ctr. (Israel)
Ifat Sher, The Chaim Sheba Medical Ctr. (Israel)


Published in SPIE Proceedings Vol. 9693:
Ophthalmic Technologies XXVI
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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