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Proceedings Paper

Development of low-cost devices for image-guided photodynamic therapy treatment of oral cancer in global health settings
Author(s): Hui Liu; Grant Rudd; Liam Daly; Joshua Hempstead; Yiran Liu; Amjad Pervez Khan; Srivalleesha Mallidi; Richard Thomas; Imran Rizvi; Stephen Arnason; Filip Cuckov; Tayyaba Hasan; Jonathan P. Celli
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Paper Abstract

Photodynamic therapy (PDT) is a light-based modality that shows promise for adaptation and implementation as a cancer treatment technology in resource-limited settings. In this context PDT is particularly well suited for treatment of pre-cancer and early stage malignancy of the oral cavity, that present a major global health challenge, but for which light delivery can be achieved without major infrastructure requirements. In recent reports we demonstrated that a prototype low-cost batterypowered 635nm LED light source for ALA-PpIX PDT achieves tumoricidal efficacy in vitro and vivo, comparable to a commercial turn-key laser source. Here, building on these reports, we describe the further development of a prototype PDT device to enable intraoral light delivery, designed for ALA- PDT treatment of precancerous and cancerous lesions of the oral cavity. We evaluate light delivery via fiber bundles and customized 3D printed light applicators for flexible delivery to lesions of varying size and position within the oral cavity. We also briefly address performance requirements (output power, stability, and light delivery) and present validation of the device for ALA-PDT treatment in monolayer squamous carcinoma cell cultures.

Paper Details

Date Published: 1 March 2016
PDF: 6 pages
Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 96940C (1 March 2016); doi: 10.1117/12.2212918
Show Author Affiliations
Hui Liu, Univ. of Massachusetts Boston (United States)
Grant Rudd, Univ. of Massachusetts Boston (United States)
Liam Daly, Univ. of Massachusetts Boston (United States)
Joshua Hempstead, Univ. of Massachusetts Boston (United States)
Yiran Liu, Univ. of Massachusetts Boston (United States)
Amjad Pervez Khan, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Srivalleesha Mallidi, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Richard Thomas, Univ. of Massachusetts Boston (United States)
Imran Rizvi, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Stephen Arnason, Univ. of Massachusetts Boston (United States)
Filip Cuckov, Univ. of Massachusetts Boston (United States)
Tayyaba Hasan, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Jonathan P. Celli, Univ. of Massachusetts Boston (United States)


Published in SPIE Proceedings Vol. 9694:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV
David H. Kessel; Tayyaba Hasan, Editor(s)

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