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Proceedings Paper

Transfer molding processes for nanoscale patterning of poly-L-lactic acid (PLLA) films
Author(s): Rabin Dhakal; Akshit Peer; Rana Biswas; Jaeyoun Kim
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Paper Abstract

Nanoscale patterned structures composed of biomaterials exhibit great potential for the fabrication of functional biostructures. In this paper, we report cost-effective, rapid, and highly reproducible soft lithographic transfer-molding techniques for creating periodic micro- and nano-scale textures on poly (L-lactic acid) (PLLA) surface. These artificial textures can increase the overall surface area and change the release dynamics of the therapeutic agents coated on it. Specifically, we use the double replication technique in which the master pattern is first transferred to the PDMS mold and the pattern on PDMS is then transferred to the PLLA films through drop-casting as well as nano-imprinting. The ensuing comparison studies reveal that the drop-cast PLLA allows pattern transfer at higher levels of fidelity, enabling the realization of nano-hole and nano-cone arrays with pitch down to ~700 nm. The nano-patterned PLLA film was then coated with rapamycin to make it drug-eluting.

Paper Details

Date Published: 18 March 2016
PDF: 6 pages
Proc. SPIE 9705, Microfluidics, BioMEMS, and Medical Microsystems XIV, 970509 (18 March 2016); doi: 10.1117/12.2212871
Show Author Affiliations
Rabin Dhakal, Iowa State Univ. (United States)
Akshit Peer, Iowa State Univ. (United States)
Microelectronics Research Ctr. (United States)
Ames Lab. (United States)
Rana Biswas, Iowa State Univ. (United States)
Microelectronics Research Ctr. (United States)
Ames Lab. (United States)
Jaeyoun Kim, Iowa State Univ. (United States)
Microelectronics Research Ctr. (United States)


Published in SPIE Proceedings Vol. 9705:
Microfluidics, BioMEMS, and Medical Microsystems XIV
Bonnie L. Gray; Holger Becker, Editor(s)

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