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Proceedings Paper

Multimodal ophthalmic imaging using swept source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography
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Paper Abstract

Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) benefit clinical diagnostic imaging in ophthalmology by enabling in vivo noninvasive en face and volumetric visualization of retinal structures, respectively. Spectrally encoding methods enable confocal imaging through fiber optics and reduces system complexity. Previous applications in ophthalmic imaging include spectrally encoded confocal scanning laser ophthalmoscopy (SECSLO) and a combined SECSLO-OCT system for image guidance, tracking, and registration. However, spectrally encoded imaging suffers from speckle noise because each spectrally encoded channel is effectively monochromatic. Here, we demonstrate in vivo human retinal imaging using a swept source spectrally encoded scanning laser ophthalmoscope and OCT (SSSESLO- OCT) at 1060 nm. SS-SESLO-OCT uses a shared 100 kHz Axsun swept source, shared scanner and imaging optics, and are detected simultaneously on a shared, dual channel high-speed digitizer. SESLO illumination and detection was performed using the single mode core and multimode inner cladding of a double clad fiber coupler, respectively, to preserve lateral resolution while improving collection efficiency and reducing speckle contrast at the expense of confocality. Concurrent en face SESLO and cross-sectional OCT images were acquired with 1376 x 500 pixels at 200 frames-per-second. Our system design is compact and uses a shared light source, imaging optics, and digitizer, which reduces overall system complexity and ensures inherent co-registration between SESLO and OCT FOVs. En face SESLO images acquired concurrent with OCT cross-sections enables lateral motion tracking and three-dimensional volume registration with broad applications in multivolume OCT averaging, image mosaicking, and intraoperative instrument tracking.

Paper Details

Date Published: 4 March 2016
PDF: 6 pages
Proc. SPIE 9693, Ophthalmic Technologies XXVI, 96930Q (4 March 2016); doi: 10.1117/12.2212859
Show Author Affiliations
Joseph D. Malone, The Cleveland Clinic (United States)
Mohamed T. El-Haddad, The Cleveland Clinic (United States)
Logan A. Tye, Case Western Reserve Univ. (United States)
Lucas Majeau, Castor Optics (Canada)
Nicolas Godbout, Castor Optics (Canada)
Ctr. d’Optique Photonique et Lasers Polytechnique Montreal (Canada)
Andrew M. Rollins, Case Western Reserve Univ. (United States)
Caroline Boudoux, Castor Optics (Canada)
Ctr. d’Optique Photonique et Lasers Polytechnique Montreal (Canada)
Yuankai K. Tao, The Cleveland Clinic (United States)


Published in SPIE Proceedings Vol. 9693:
Ophthalmic Technologies XXVI
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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