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Proceedings Paper

Preanalytical considerations in detection of colorectal cancer in blood serum using Raman molecular imaging (Conference Presentation)
Author(s): Patrick J. Treado; Shona D. Stewart; Aaron Smith; Heather Kirschner; Christopher Post; Bergein F. Overholt
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Paper Abstract

Colorectal cancer (CRC) is the third most common cancer in men and women in the United States. Raman Molecular Imaging (RMI) is an effective technique to evaluate human tissue, cells and bodily fluids, including blood serum for disease diagnosis. ChemImage Corporation, in collaboration with clinicians, has been engaged in development of an in vitro diagnostic Raman assay focused on CRC detection. The Raman Assay for Colorectal Cancer (RACC) exploits the high specificity of Raman imaging to distinguish diseased from normal dried blood serum droplets without additional reagents. Pilot Study results from testing of hundreds of biobank patient samples have demonstrated that RACC detects CRC with high sensitivity and specificity. However, expanded clinical trials, which are ongoing, are revealing a host of important preanalytical considerations associated with sample collection, sample storage and stability, sample shipping, sample preparation and sample interferents, which impact detection performance. Results from recent clinical studies will be presented.

Paper Details

Date Published: 3 May 2016
PDF: 1 pages
Proc. SPIE 9704, Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry, 970409 (3 May 2016); doi: 10.1117/12.2212776
Show Author Affiliations
Patrick J. Treado, ChemImage Corp. (United States)
Shona D. Stewart, ChemImage Corp. (United States)
Aaron Smith, ChemImage Corp. (United States)
Heather Kirschner, ChemImage Corp. (United States)
Christopher Post, ChemImage Corp. (United States)
Bergein F. Overholt, Gastrointestinal Associates, P.C. (United States)

Published in SPIE Proceedings Vol. 9704:
Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry
Anita Mahadevan-Jansen; Wolfgang Petrich, Editor(s)

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