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Proceedings Paper

Towards optical fibre based Raman spectroscopy for the detection of surgical site infection
Author(s): Alex J. Thompson; Lukasz Koziej; Huw D. Williams; Daniel S. Elson; Guang-Zhong Yang
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Paper Abstract

Surgical site infections (SSIs) are common post-surgical complications that remain significant clinical problems, as they are associated with substantial mortality and morbidity. As such, there is significant interest in the development of minimally invasive techniques that permit early detection of SSIs. To this end, we are applying a compact, clinically deployable Raman spectrometer coupled to an optical fibre probe to the study of bacteria, with the long term goal of using Raman spectroscopy to detect infection in vivo. Our system comprises a 785 nm laser diode for excitation and a commercial (Ocean Optics, Inc.) Raman spectrometer for detection. Here we discuss the design, optimisation and validation of this system, and describe our first experiences interrogating bacterial cells (Escherichia coli) in vitro.

Paper Details

Date Published: 7 March 2016
PDF: 6 pages
Proc. SPIE 9704, Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry, 970414 (7 March 2016); doi: 10.1117/12.2212769
Show Author Affiliations
Alex J. Thompson, Imperial College London (United Kingdom)
Lukasz Koziej, Imperial College London (United Kingdom)
Huw D. Williams, Imperial College London (United Kingdom)
Daniel S. Elson, Imperial College London (United Kingdom)
Guang-Zhong Yang, Imperial College London (United Kingdom)

Published in SPIE Proceedings Vol. 9704:
Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry
Anita Mahadevan-Jansen; Wolfgang Petrich, Editor(s)

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